NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Madrid E;
DOI=10.1038/24094; PubMed=9823893 [NCBI, ExPASy, EBI, Israel, Japan]
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.;
"The genome sequence of Rickettsia prowazekii and the origin of mitochondria.";
Nature 396:133-140(1998).

[2]

DOMAIN RPE1.
DOI=10.1126/science.290.5490.347; PubMed=11030655 [NCBI, ExPASy, EBI, Israel, Japan]
Ogata H., Audic S., Barbe V., Artiguenave F., Fournier P.-E., Raoult D., Claverie J.-M.;
"Selfish DNA in protein-coding genes of Rickettsia.";
Science 290:347-350(2000).

Comments

CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 1/4 .
PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3 .
PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5 .
SIMILARITY: Belongs to the aspartokinase family.
SIMILARITY: Contains 1 RPE1 insert domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ235273; CAA15181.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

E71635; E71635.

RefSeq

NP_221105.1; -.

3D structure databases

ModBase

Q9ZCI7.

Enzyme and pathway databases

BioCyc

RPRO272947:RP753-MON; -.

Ontologies

GO:0004072;	Molecular function: aspartate kinase activity (inferred from electronic annotation from InterPro).
GO:0004349;	Molecular function: glutamate 5-kinase activity (inferred from electronic annotation from InterPro).
GO:0019877;	Biological process: diaminopimelate biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0006561;	Biological process: proline biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR001048; Asp/Glu/Uridylate_kinase.
IPR001341; Asp_kin_reg.
IPR001057; Glu_5kinase.
IPR005728; Rickett_RPE.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.1160.10; Aa_kinase; 1.

Pfam

PF00696; AA_kinase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00474; GLU5KINASE.

TIGRFAMs

TIGR00657; asp_kinases; 1.
TIGR01045; RPE; 1.

PROSITE

PS00324; ASPARTOKINASE; 1.

ProtoNet

Q9ZCI7.

Genome annotation databases

GeneID

883748; -.

GenomeReviews

AJ235269_GR; RP753.

KEGG

rpr:RP753; -.

Phylogenomic databases

HOGENOM

Q9ZCI7; -.

Genome annotation databases

CMR

Q9ZCI7; RP753.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Diaminopimelate biosynthesis; Kinase; Lysine biosynthesis; Transferase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 446`	`446`	`Aspartokinase.`	`PRO_0000066680`
`DOMAIN`	`250 294`	`45`	`RPE1 insert.`

Sequence information

Length: 446 AA [This is the length of the unprocessed precursor]

Molecular weight: 49773 Da [This is the MW of the unprocessed precursor]

CRC64: 76E118506A4E3D86 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MALIIQKFGG TSVANVERIK KLVPIIKAEI AKNNQVIVVV SAMAGVTNQL VTLCNEVSSL 

        70         80         90        100        110        120 
NKRSQFAEYD VALSSGEIVT ASLLALALQE EEIKAQSLLA WQLPIRTNNN YSKALVEFIT 

       130        140        150        160        170        180 
TDLLEKYLQL KIIPIIAGFQ GINKSNRVTT LGRGGSDTTA ALIAAAMKAD RCDIYTDVDG 

       190        200        210        220        230        240 
IFTADPRIIP NAKRIKEIDF LEMLELASSG AKVLHPRAVE LVMRYKIDMR VLSTFSPNTE 

       250        260        270        280        290        300 
GTLITSKDTI PLVKSTYMEE SALNTKHSTK IDIPEDASGS TYKLPIELAL QNRYNMENCV 

       310        320        330        340        350        360 
VRCITSNKNL LKVSVNSISL SFLQVANMIT YNNNCIEFMQ EIENNIEYNF ITNLTDKNNL 

       370        380        390        400        410        420 
QTLLTKCKNN KQIQDFTFDT EIATISLIGY GIKNDCKLLT MILSQLTQDN INVHMMQLSE 

       430        440 
VKITLLINDK DVEKTIFNLY NLFKIS

Q9ZCI7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools