[1]	NUCLEOTIDE SEQUENCE [MRNA]. Ha S.H., Kim J.B., Lee S.W., Hwang Y.S.; "Pathogen-inducible HMGR2 gene from hot pepper."; Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants.
CATALYTIC ACTIVITY: (R)-mevalonate + CoA + 2 NADP⁺ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.
PATHWAY: Metabolic intermediate biosynthesis; mevalonic acid biosynthesis; (R)-mevalonic acid from acetyl-CoA: step 3/3 .
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the HMG-CoA reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF110383; AAD28179.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P04035; 1DQA. [HSSP ENTRY / PDB]

ModBase

Q9XEL8.

Ontologies

GO:0005789;	Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0004420;	Molecular function: hydroxymethylglutaryl-CoA reductase (NADPH) activity (inferred from electronic annotation from InterPro).
GO:0050661;	Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0015936;	Biological process: coenzyme A metabolic process (inferred from electronic annotation from InterPro).
GO:0008299;	Biological process: isoprenoid biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.

Gene3D

G3DSA:3.90.770.10; HMG-CoA_red; 1.

PANTHER

PTHR10572; HMG-CoA_red; 1.

Pfam

PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.

PRINTS

PR00071; HMGCOARDTASE.

TIGRFAMs

TIGR00533; HMG_CoA_R_NADP; 1.

PROSITE

PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

Q9XEL8.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Endoplasmic reticulum; Glycoprotein; Isoprene biosynthesis; Membrane; NADP; Oxidoreductase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 604`	`604`	`3-hydroxy-3-methylglutaryl-coenzyme A reductase 2.`	`PRO_0000114436`
`TRANSMEM`	`47 67`	`21`	`Potential.`
`TRANSMEM`	`91 111`	`21`	`Potential.`
`REGION`	`112 188`	`77`	`Linker (By similarity).`
`REGION`	`189 604`	`416`	`Catalytic (By similarity).`
`ACT_SITE`	`283 283`		`Charge relay system (By similarity).`
`ACT_SITE`	`415 415`		`Charge relay system (By similarity).`
`ACT_SITE`	`491 491`		`Charge relay system (By similarity).`
`ACT_SITE`	`589 589`		`Proton donor (By similarity).`
`CARBOHYD`	`120 120`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`347 347`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`460 460`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`593 593`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 604 AA [This is the length of the unprocessed precursor]

Molecular weight: 64881 Da [This is the MW of the unprocessed precursor]

CRC64: CCCE77884BC5A362 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDVRRRSEEA VYSSKVFAAD EKPLKPHKQQ QEEDNTLLID ASDALPLPLY FTNGLFFTMF 

        70         80         90        100        110        120 
FSVMYFLLSR WREKIRNSTP LHVVTLSELG AIVSLIASVI YLLGFFGIGF VQTFVARGNN 

       130        140        150        160        170        180 
DSWDEEDEND EQFILEEDSR RGPCAAATTL GCAVPTPPAK HIAPIVPQQP AVSIAEKPAP 

       190        200        210        220        230        240 
LVTPAASEED EEIIKSVVQG KIPSYSLESK LGDCKRAASI RKEVLQRITG KSLEGLPLDG 

       250        260        270        280        290        300 
FNYESILGQC CEMTIGYVQI PVGIAGPLLL NGREYSVPMA TTEGCLVAST NRGCKAIYAS 

       310        320        330        340        350        360 
GGATSILLRD GMTRAPCVRF GTAKRAAELK FFVEDPINFE TLANVFNQSS RFARLQRIQC 

       370        380        390        400        410        420 
AIAGKNLHMR FVCSTGDAMG MNMVSKGVQN VLDYLQNEYA DMDVIGISAN FCSDKKPAAV 

       430        440        450        460        470        480 
NWIEGRGKSV VCEAIITEEV VKKVLKTEVA ALVELNMLKN LTGSALAGAL GGFNAHASNI 

       490        500        510        520        530        540 
VSAVYIATGQ DPAQNIESSH CITMMEAVND GKDLHISVTM PSIEVGTVGG GTQLASQSAC 

       550        560        570        580        590        600 
LNLLGVKGAN REAPGSNARL LATIVAGSVL AGELSLMSAI SAGQLVNSHM KYNRSTKDVT 


KASS

Q9XEL8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools