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UniProtKB/Swiss-Prot entry Q9UWX9


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ILVC1_SULSO
Primary accession number Q9UWX9
Secondary accession numbers None
Integrated into Swiss-Prot on August 29, 2001
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 53)
Name and origin of the protein
Protein name Ketol-acid reductoisomerase 1
Synonyms EC 1.1.1.86
Acetohydroxy-acid isomeroreductase 1
Alpha-keto-beta-hydroxylacil reductoisomerase 1
Gene name
Name: ilvC1
Synonyms: ilvC, ilvC-1
OrderedLocusNames: SSO0576
From
Sulfolobus solfataricus [TaxID: 2287] [HAMAP proteome]
Taxonomy Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Sulfolobus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
DOI=10.1139/gen-43-1-116; PubMed=10701121 [NCBI, ExPASy, EBI, Israel, Japan]
Charlebois R.L., Singh R.K., Chan-Weiher C.C.-Y., Allard G., Chow C., Confalonieri F., Curtis B., Duguet M., Erauso G., Faguy D., Gaasterland T., Garrett R.A., Gordon P., Jeffries A.C., Kozera C., Kushwaha N., Lafleur E., Medina N., Peng X., Penny S.L., She Q., St Jean A., van der Oost J., Young F., Zivanovic Y., Doolittle W.F., Ragan M.A., Sensen C.W.;
"Gene content and organization of a 281-kbp contig from the genome of the extremely thermophilic archaeon, Sulfolobus solfataricus P2.";
Genome 43:116-136(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
DOI=10.1073/pnas.141222098; PubMed=11427726 [NCBI, ExPASy, EBI, Israel, Japan]
She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
"The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y18930; CAB57724.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE006687; AAK40890.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C90204; C90204.
RefSeq NP_342100.1; -.
3D structure databases
HSSP Q9HVA2; 1NP3. [HSSP ENTRY / PDB]
ModBase Q9UWX9.
Enzyme and pathway databases
BioCyc SSOL273057:SSO0576-MON; -.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004455; Molecular function: ketol-acid reductoisomerase activity (inferred from electronic annotation from HAMAP).
GO:0009097; Biological process: isoleucine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0009099; Biological process: valine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00435; -; 1.
PBIL [Tree]
InterPro IPR013023; AcH_isomrdctse.
IPR000506; AcH_isomrdctse_C.
IPR013116; IlvN.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR21371; AcH_isomrdctse; 1.
Pfam PF01450; IlvC; 1.
PF07991; IlvN; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00465; ilvC; 1.
ProtoNet Q9UWX9.
Genome annotation databases
GeneID 1454857; -.
GenomeReviews AE006641_GR; SSO0576.
KEGG sso:SSO0576; -.
NMPDR fig|273057.1.peg.523; -.
Phylogenomic databases
HOGENOM Q9UWX9; -.
Genome annotation databases
CMR Q9UWX9; SSO0576.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   335  335     Ketol-acid reductoisomerase 1. PRO_0000151400
ACT_SITE   111   111        Potential. 
Sequence information
Length: 335 AA [This is the length of the unprocessed precursor] Molecular weight: 36811 Da [This is the MW of the unprocessed precursor] CRC64: 3246B80649CA0516 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKCTSKIYTD NDANLDLIKG KRIAVLGYGS QGRAWAQNLR DSGLNVVVGL EREGKSWELA 

        70         80         90        100        110        120 
KSDGITPLHT KDAVKDADII IFLVPDMVQR TLWLESVQPY MKKGADLVFA HGFNIHYKLI 

       130        140        150        160        170        180 
DPPKDSDVYM IAPKGPGPTV REYYKAGGGV PALVAVHQDV SGTALHKALA IAKGIGATRA 

       190        200        210        220        230        240 
GVIPTTFKEE TETDLFGEQV ILVGGIMELM RAAFETLVEE GYQPEVAYFE TINELKMLVD 

       250        260        270        280        290        300 
LVYEKGISGM LKAVSDTAKY GGMTVGKFVI DESVRKRMKE ALQRIKSGKF AEEWVEEYGR 

       310        320        330 
GMPTVVNGLS NVQNSLEEKI GNQLRDLVQK GKPKS 

Q9UWX9 in FASTA format

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