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UniProtKB/Swiss-Prot entry Q9KNI1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FADB_VIBCH
Primary accession number Q9KNI1
Secondary accession numbers None
Integrated into Swiss-Prot on October 31, 2006
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 46)
Name and origin of the protein
Protein name Fatty acid oxidation complex subunit alpha
Synonyms None
Includes Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase
     (EC 4.2.1.17)
     (EC 5.3.3.8)
     (EC 5.1.2.3)
3-hydroxyacyl-CoA dehydrogenase
     (EC 1.1.1.35)
Gene name
Name: fadB
OrderedLocusNames: VC_2758
From
Vibrio cholerae [TaxID: 666] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 39315 / El Tor Inaba N16961 / Serotype O1;
DOI=10.1038/35020000; PubMed=10952301 [NCBI, ExPASy, EBI, Israel, Japan]
Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.";
Nature 406:477-483(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE003852; AAF95897.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H82035; H82035.
RefSeq NP_232384.1; -.
3D structure databases
HSSP P00348; 3HDH. [HSSP ENTRY / PDB]
ModBase Q9KNI1.
Ontologies
GO
GO:0016507; Cellular component: fatty acid beta-oxidation multienzyme complex (inferred from electronic annotation from InterPro).
GO:0003857; Molecular function: 3-hydroxyacyl-CoA dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0008692; Molecular function: 3-hydroxybutyryl-CoA epimerase activity (inferred from electronic annotation from HAMAP).
GO:0050662; Molecular function: coenzyme binding (inferred from electronic annotation from InterPro).
GO:0004165; Molecular function: dodecenoyl-CoA delta-isomerase activity (inferred from electronic annotation from HAMAP).
GO:0004300; Molecular function: enoyl-CoA hydratase activity (inferred from electronic annotation from HAMAP).
GO:0009062; Biological process: fatty acid catabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01621; -; 1.
PBIL [Tree]
InterPro IPR006180; 3-OHacyl-CoA_DHase_CS.
IPR006176; 3-OHacyl-CoA_DHase_NAD-bd.
IPR006108; 3HC_DHase_C.
IPR001753; Crotonase_core.
IPR013328; DHase_multihelical.
IPR012799; FadB.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 2.
Pfam PF00725; 3HCDH; 1.
PF02737; 3HCDH_N; 1.
PF00378; ECH; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR02437; FadB; 1.
PROSITE PS00067; 3HCDH; 1.
PS00166; ENOYL_COA_HYDRATASE; FALSE_NEG.
ProtoNet Q9KNI1.
Genome annotation databases
GeneID 2614935; -.
GenomeReviews AE003852_GR; VC_2758.
KEGG vch:VC2758; -.
TIGR VC_2758; -.
Phylogenomic databases
HOGENOM Q9KNI1; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Fatty acid metabolism; Isomerase; Lipid degradation; Lipid metabolism; Lyase; Multifunctional enzyme; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   723  723     Fatty acid oxidation complex subunit alpha. PRO_0000255846
REGION   1   189  189     Enoyl-CoA hydratase/isomerase (By similarity). 
REGION   312   723  412     3-hydroxyacyl-CoA dehydrogenase (By similarity). 
Sequence information
Length: 723 AA [This is the length of the unprocessed precursor] Molecular weight: 78108 Da [This is the MW of the unprocessed precursor] CRC64: 147F5ABD0B0797F8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MIYQAKTLQV KQLANGIAEL SFCAPASVNK LDLHTLESLD KALDALAADS SVKGLLLSSD 

        70         80         90        100        110        120 
KEAFIVGADI TEFLGLFAKP EAELDEWLQF ANRIFNKLED LPFPTLSALK GHTLGGGCEC 

       130        140        150        160        170        180 
VLATDFRIGD ATTSIGLPET KLGIMPGFGG TVRLPRLIGA DSAMEIITQG KACRAEEALK 

       190        200        210        220        230        240 
VGLLDAIVDS DKLIDSAITT LTQAIEEKLD WQKRRQQKTS ALTLSKLEAM MSFTMAKGMV 

       250        260        270        280        290        300 
AQVAGKHYPA PMTSVVTIEE AARLPRDAAL DIERKHFIKL AKSTEAQALV GIFLNDQYIK 

       310        320        330        340        350        360 
GLAKQSAKAA SQDTQHAAVL GAGIMGGGIA YQSALKGVPV LMKDIAPHSL ELGMTEAAKL 

       370        380        390        400        410        420 
LNKQLERGKI DGFKMAGILA SITPSLHYAG IDQADVIVEA VVENPKVKAA VLSEVEGLVD 

       430        440        450        460        470        480 
TETILTSNTS TIPINLLAKS LKRPQNFCGM HFFNPVHRMP LVEIIRGEHT SEDTINRVVA 

       490        500        510        520        530        540 
YAAKMGKSPI VVNDCPGFFV NRVLFPYFAG FSLLMRDGAN FTEIDKVMER QFGWPMGPAY 

       550        560        570        580        590        600 
LLDVVGIDTA HHAQAVMAEG FPTRMAKSGR EAIDALYEAK KFGQKNGSGF YQYTVDKKGK 

       610        620        630        640        650        660 
PKKAFSDDVL AILAPVCGAP QSFDPQTLIE RTMIPMINEV VLCLEEGIIA SAQEADMALV 

       670        680        690        700        710        720 
YGLGFPPFRG GVFRYLDTIG IANYVAMAEK YADLGALYQV PQLLKNMAQQ GTSFYSAQQV 


SAL
Q9KNI1 in FASTA format

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