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UniProtKB/Swiss-Prot entry Q9BUT1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BDH2_HUMAN
Primary accession number Q9BUT1
Secondary accession numbers Q503A0 Q6IA46 Q6UWD3 Q9H8S8 Q9NRX8
Integrated into Swiss-Prot on October 11, 2005
Sequence was last modified on February 6, 2007 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 64)
Name and origin of the protein
Protein name 3-hydroxybutyrate dehydrogenase type 2
Synonyms EC 1.1.1.30
R-beta-hydroxybutyrate dehydrogenase
Dehydrogenase/reductase SDR family member 6
Oxidoreductase UCPA
Gene name
Name: BDH2
Synonyms: DHRS6
ORFNames: UNQ6308/PRO20933
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Hypothalamus;
DOI=10.1073/pnas.160270997; PubMed=10931946 [NCBI, ExPASy, EBI, Israel, Japan]
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.;
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.";
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-70.
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT SER-70.
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Ovary;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT SER-70.
TISSUE=Brain, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
[7]
X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) IN COMPLEX WITH NAD, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND SUBUNIT.
DOI=10.1074/jbc.M511346200; PubMed=16380372 [NCBI, ExPASy, EBI, Israel, Japan]
Guo K., Lukacik P., Papagrigoriou E., Meier M., Lee W.H., Adamski J., Oppermann U.;
"Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase.";
J. Biol. Chem. 281:10291-10297(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF164790; AAF80754.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358841; AAQ89200.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR457309; CAG33590.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK023323; BAB14526.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC037277; AAH37277.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001953; AAH01953.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC095414; AAH95414.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_064524.3; -.
UniGene Hs.124696
3D structure databases
PDB
2AG5; X-ray; 1.84 A; A/B/C/D=1-245.[ExPASy / RCSB / EBI]
PDBsum 2AG5; -.
ModBase Q9BUT1.
PTM databases
PhosphoSite Q9BUT1; -.
Organism-specific databases
H-InvDB HIX0004415; -.
HGNC HGNC:32389; BDH2.
GenAtlas BDH2.
PharmGKB PA142672559; -.
GeneCards Q9BUT1.
Gene expression databases
ArrayExpress Q9BUT1; -.
CleanEx HS_BDH2; -.
GermOnline ENSG00000164039; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from HGNC).
GO:0003858; Molecular function: 3-hydroxybutyrate dehydrogenase activity (inferred from direct assay from HGNC).
GO:0051287; Molecular function: NAD binding (inferred from direct assay from HGNC).
GO:0006635; Biological process: fatty acid beta-oxidation (inferred from direct assay from HGNC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR00081; GDHRDH.
PR00080; SDRFAMILY.
PROSITE PS00061; ADH_SHORT; 1.
ProtoNet Q9BUT1.
Genome annotation databases
Ensembl ENSG00000164039; Homo sapiens. [Contig view]
GeneID 56898; -.
KEGG hsa:56898; -.
Phylogenomic databases
HOGENOM Q9BUT1; -.
HOVERGEN Q9BUT1; -.
Other
NextBio 62339; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Cytoplasm; NAD; Oxidoreductase; Phosphoprotein; Polymorphism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   245  245     3-hydroxybutyrate dehydrogenase type 2. PRO_0000042580
NP_BIND   10    37  28     NAD. 
NP_BIND   180   184  5     NAD. 
ACT_SITE   147   147        Proton acceptor (By similarity). 
BINDING   58    58        NAD. 
BINDING   144   144        Substrate (Probable). 
BINDING   151   151        NAD. 
BINDING   188   188        Substrate (Probable). 
BINDING   205   205        Substrate (Probable). 
MOD_RES   132   132        Phosphoserine. 
VAR_SEQ   141   245        VVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTV DTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAML CVYLASDESAYVTGNPVIIDGGWSL -> GSVSFRGLRCSYTHIIKSSAFGNRHSRDYNFKY (in isoform 2). VSP_015859
VARIANT   70    70  1     N -> S (in dbSNP:rs1054707 [NCBI]). VAR_023602 
CONFLICT   161   161        V -> L (in Ref. 2; AAQ89200). 
CONFLICT   230   230        A -> T (in Ref. 5; AAH95414). 
TURN   3     6  4      
STRAND   8    13  6      
HELIX   17    28  12      
STRAND   32    38  7      
HELIX   40    43  4      
HELIX   44    48  5      
STRAND   52    56  5      
HELIX   62    71  10      
STRAND   76    80  5      
HELIX   90    92  3      
HELIX   95   105  11      
HELIX   107   123  17      
STRAND   126   131  6      
TURN   136   138  3      
HELIX   145   165  21      
HELIX   166   168  3      
STRAND   170   178  9      
HELIX   183   191  9      
STRAND   192   194  3      
HELIX   195   204  10      
HELIX   214   225  12      
HELIX   227   229  3      
STRAND   236   239  4      
Sequence information
Length: 245 AA [This is the length of the unprocessed precursor] Molecular weight: 26724 Da [This is the MW of the unprocessed precursor] CRC64: A6E10E9DF9304107 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP GIQTRVLDVT 

        70         80         90        100        110        120 
KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF SMNLNVRSMY LMIKAFLPKM 

       130        140        150        160        170        180 
LAQKSGNIIN MSSVASSVKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV 

       190        200        210        220        230        240 
DTPSLQERIQ ARGNPEEARN DFLKRQKTGR FATAEEIAML CVYLASDESA YVTGNPVIID 


GGWSL 

Q9BUT1 in FASTA format

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