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UniProtKB/Swiss-Prot entry Q99ZM2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHD_STRP1
Primary accession number Q99ZM2
Secondary accession number Q48YR4
Integrated into Swiss-Prot on November 28, 2003
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 51)
Name and origin of the protein
Protein name D-lactate dehydrogenase
Synonyms D-LDH
EC 1.1.1.28
D-specific D-2-hydroxyacid dehydrogenase
Gene name
Name: ldhD
Synonyms: ddh
OrderedLocusNames: SPy_1170, M5005_Spy0890
From
Streptococcus pyogenes serotype M1 [TaxID: 301447] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700294 / SF370 / Serotype M1;
DOI=10.1073/pnas.071559398; PubMed=11296296 [NCBI, ExPASy, EBI, Israel, Japan]
Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E.;
"Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
DOI=10.1086/432514; PubMed=16088826 [NCBI, ExPASy, EBI, Israel, Japan]
Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.;
"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.";
J. Infect. Dis. 192:771-782(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE004092; AAK34037.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CP000017; AAZ51508.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_269316.1; -.
YP_282253.1; -.
3D structure databases
HSSP P17584; 1DXY. [HSSP ENTRY / PDB]
ModBase Q99ZM2.
Enzyme and pathway databases
BioCyc SPYO160490:SPY1170-MON; -.
SPYO293653:M5005_SPY0890-MON; -.
Ontologies
GO
GO:0008720; Molecular function: D-lactate dehydrogenase activity (inferred from electronic annotation from EC).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006139; D-isomer_2_OHA_DHase.
IPR006140; D-isomer_2_OHA_DHase_NAD-bd.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00389; 2-Hacid_dh; 1.
PF02826; 2-Hacid_dh_C; 1.
Pfam graphical view of domain structure.
PROSITE PS00065; D_2_HYDROXYACID_DH_1; 1.
PS00670; D_2_HYDROXYACID_DH_2; FALSE_NEG.
PS00671; D_2_HYDROXYACID_DH_3; 1.
ProtoNet Q99ZM2.
Genome annotation databases
GeneID 3572021; -.
901282; -.
GenomeReviews CP000017_GR; M5005_Spy0890.
AE004092_GR; SPy_1170.
KEGG spy:SPy_1170; -.
spz:M5005_Spy_0890; -.
Phylogenomic databases
HOGENOM Q99ZM2; -.
Genome annotation databases
CMR Q99ZM2; SPy_1170.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   330  330     D-lactate dehydrogenase. PRO_0000075970
ACT_SITE   235   235        By similarity. 
ACT_SITE   264   264        By similarity. 
ACT_SITE   296   296        Proton donor (By similarity). 
Sequence information
Length: 330 AA [This is the length of the unprocessed precursor] Molecular weight: 36126 Da [This is the MW of the unprocessed precursor] CRC64: 34897A432723B092 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKLKLYNVRG EEAVLAKKWA DDNGIEISLT ESPLTPETVK EAEGFDGIAN AQIGPLDDAI 

        70         80         90        100        110        120 
YPLLKEMGIK QIAQHSASVD MYNLDLATEN DIIITNVPSY SPESIAEFTV TIVLNLIRHV 

       130        140        150        160        170        180 
ELIRENVKKQ NFTWGLPIRG RVLGDMTVAI IGTGRIGLAT AKIFKGFGCK VVGYDIYQSD 

       190        200        210        220        230        240 
AAKAVLDYKE SVEEAIKDAD LVSLHMPPTA ENTHLFNSDL FKSFKKGAIL MNMARGAVIE 

       250        260        270        280        290        300 
TQDLLDALDA GLLSGAGIDT YEFEGPYIPK NFEGQEITDS LFKALINHPK VIYTPHAAYY 

       310        320        330 
TDEAVKNLVE GALNATVEII KTGTTTTRVN 

Q99ZM2 in FASTA format

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