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UniProtKB/Swiss-Prot entry Q93353

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH3B_CAEEL
Primary accession number Q93353
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on February 1, 1997 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 56)
Name and origin of the protein
Protein name Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [Precursor]
Synonyms EC 1.1.1.41
Isocitric dehydrogenase
NAD(+)-specific ICDH
Gene name
ORFNames: C37E2.1
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z81046; CAB02822.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T19810; T19810.
RefSeq NP_510362.1; -.
UniGene Cel.8914
3D structure databases
HSSP P00351; 1DPZ. [HSSP ENTRY / PDB]
ModBase Q93353.
Protein-protein interaction databases
DIP DIP:27476N; -.
IntAct Q93353; -.
Organism-specific databases
WormBase WBGene00007993; C37E2.1.
WormPep C37E2.1; CE08620. [WormPep / WorfDB]
Gene expression databases
ArrayExpress Q93353; -.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from electronic annotation from InterPro).
GO:0004449; Molecular function: isocitrate dehydrogenase (NAD+) activity (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR004434; IsoCit_DHase_NAD_mit.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00175; mito_nad_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
ProtoNet Q93353.
Genome annotation databases
Ensembl C37E2.1; Caenorhabditis elegans. [Contig view]
GeneID 181528; -.
KEGG cel:C37E2.1; -.
Other
NextBio 914316; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    31  31     Mitochondrion (By similarity). 
CHAIN   32   379  348     Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial. PRO_0000014448
NP_BIND   44    72  29     NAD (Potential). 
METAL   248   248        Magnesium or manganese (By similarity). 
BINDING   129   129        Substrate (By similarity). 
BINDING   161   161        Substrate (By similarity). 
BINDING   248   248        Substrate (By similarity). 
SITE   168   168  1     Critical for catalysis (By similarity). 
SITE   215   215  1     Critical for catalysis (By similarity). 
Sequence information
Length: 379 AA [This is the length of the unprocessed precursor] Molecular weight: 41553 Da [This is the MW of the unprocessed precursor] CRC64: F099425960AB3086 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLSRTVSSLS RVAPQTLGAV NAASSRQYSI TAPRPPTELN QKLKVTIIPG DGVGPELIYT 

        70         80         90        100        110        120 
VQDIVKQTGI PIEFEEIFLS EVHYTRSSSI ENAVESIGRN NNVALKGAIE ESAVLHTEGE 

       130        140        150        160        170        180 
LQGLNMRLRR SLDLFANVVH IKTLDGIKTR HGKQLDFVIV REQTEGEYSS LEHELVPGVI 

       190        200        210        220        230        240 
ECLKISTRTK AERIAKFAFD YATKTGRKKV TAVHKANIMK LGDGLFLRTC EGVAKQYPKI 

       250        260        270        280        290        300 
QFESMIIDNT CMQLVSKPEQ FDVMVMPNLY GNIIDNLAAG LVGGAGVVPG QSVGRDFVIF 

       310        320        330        340        350        360 
EPGSRHSFQE AMGRSIANPT AMILCAANML NHLHLDAWGN SLRQAVADVV KEGKVRTRDL 

       370 
GGYATTVDFA DAVIDKFRI
Q93353 in FASTA format

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