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UniProtKB/Swiss-Prot entry Q930I4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX2_RHIME
Primary accession number Q930I4
Secondary accession numbers None
Integrated into Swiss-Prot on March 25, 2003
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 50)
Name and origin of the protein
Protein name Histidinol dehydrogenase 2
Synonyms HDH 2
EC 1.1.1.23
Gene name
Name: hisD2
OrderedLocusNames: RA0212
ORFNames: SMa0398
From
Rhizobium meliloti (Sinorhizobium meliloti) [TaxID: 382] [HAMAP proteome]
Encoded on Plasmid pSymA (megaplasmid 1).
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=1021;
DOI=10.1073/pnas.161294798; PubMed=11481432 [NCBI, ExPASy, EBI, Israel, Japan]
Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F., Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L., Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H., Palm C., Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A., Long S.R.;
"Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid.";
Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE006469; AAK64870.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D95288; D95288.
RefSeq NP_435458.3; -.
3D structure databases
HSSP P06988; 1K75. [HSSP ENTRY / PDB]
ModBase Q930I4.
Enzyme and pathway databases
BioCyc SMEL266834:SMA0398-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01024; atypical; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
ProtoNet Q930I4.
Genome annotation databases
GeneID 1235437; -.
GenomeReviews AE006469_GR; RA0212.
KEGG sme:SMa0398; -.
NMPDR fig|266834.1.peg.212; -.
Phylogenomic databases
HOGENOM Q930I4; -.
Genome annotation databases
CMR Q930I4; RA0212.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Plasmid; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   456  456     Histidinol dehydrogenase 2. PRO_0000135833
ACT_SITE   347   347        Proton acceptor (By similarity). 
ACT_SITE   348   348        Proton acceptor (By similarity). 
METAL   276   276        Zinc (By similarity). 
METAL   279   279        Zinc (By similarity). 
METAL   440   440        Zinc (By similarity). 
Sequence information
Length: 456 AA [This is the length of the unprocessed precursor] Molecular weight: 48702 Da [This is the MW of the unprocessed precursor] CRC64: 958D34D91C28DEEA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTLRPQLARY KDKTMTSVSF YEYSKLNAEE KAALLRRSET DISGFIEKVA PILEAVRTEG 

        70         80         90        100        110        120 
DKALARFGRE LDKADVTEAN LKVTAAEFDA AFKLVDASVL ESVQFGIDNI RKFHEEQKPE 

       130        140        150        160        170        180 
AMWLKEIRPG AFAGDRFTPI QSVALYVPRG KGSFPSVTMM TSVPAVVAGV PNLAIVTPPA 

       190        200        210        220        230        240 
PDGSVDAATL VAARLAGVET VYKAGGAQAV AAVAYGTETV KPALKIVGPG SPWVVAAKRS 

       250        260        270        280        290        300 
LSGVIDTGLP AGPSEVMILA DDTVHGGLAA LDLLIEAEHG PDSSAYLVTH SGRVAEEALA 

       310        320        330        340        350        360 
ALPEHWARMT EQRTAFSKTV LSGKTGGIVL TSSIEESYEF VNAYAPEHLE LLSEQPFIHL 

       370        380        390        400        410        420 
GHITEASEIL MGTHTPVSIA NFSLGPNAVL PTSRWARTFG PLSVTDFVKR SSIGYVTAPA 

       430        440        450 
YPEFARHSHN LAIYEGFSSH ALAVSPVRDA YLKKGA
Q930I4 in FASTA format

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