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UniProtKB/Swiss-Prot entry Q92BI0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH2_LISIN
Primary accession number Q92BI0
Secondary accession numbers None
Integrated into Swiss-Prot on June 21, 2004
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 44)
Name and origin of the protein
Protein name L-lactate dehydrogenase 2
Synonyms L-LDH 2
EC 1.1.1.27
Gene name
Name: ldh2
OrderedLocusNames: lin1569
From
Listeria innocua [TaxID: 1642] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Listeriaceae; Listeria.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CLIP 11262 / Serovar 6a;
DOI=10.1126/science.1063447; PubMed=11679669 [NCBI, ExPASy, EBI, Israel, Japan]
Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
"Comparative genomics of Listeria species.";
Science 294:849-852(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL596169; CAC96800.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AH1628; AH1628.
RefSeq NP_470905.1; -.
3D structure databases
HSSP P00344; 1LDB. [HSSP ENTRY / PDB]
ModBase Q92BI0.
Enzyme and pathway databases
BioCyc LINN272626:LIN1569-MON; -.
Organism-specific databases
ListiList LIN01569; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
ProtoNet Q92BI0.
Genome annotation databases
GeneID 1130186; -.
GenomeReviews AL592022_GR; lin1569.
KEGG lin:lin1569; -.
NMPDR fig|272626.1.peg.1558; -.
Phylogenomic databases
HOGENOM Q92BI0; -.
Genome annotation databases
CMR Q92BI0; lin1569.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   311  311     L-lactate dehydrogenase 2. PRO_0000168362
NP_BIND   12    40  29     NAD (By similarity). 
ACT_SITE   177   177        Proton acceptor (By similarity). 
BINDING   90    90        Substrate (By similarity). 
BINDING   122   122        NAD or substrate (By similarity). 
BINDING   153   153        Substrate (By similarity). 
BINDING   230   230        Substrate (By similarity). 
Sequence information
Length: 311 AA [This is the length of the unprocessed precursor] Molecular weight: 33854 Da [This is the MW of the unprocessed precursor] CRC64: F953C292AEA87E10 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKPRKVMIIG AGNVGSAAAH AFVNQKFVEE LILVDLNKER VEGNRKDLAD AAAFMSGKMD 

        70         80         90        100        110        120 
ISVREASDCA DVDIAVITVT AGPLKEGQTR LDELRSTSRI VASIVPEMMK GGFKGIFLIA 

       130        140        150        160        170        180 
TNPCDIITYQ VWKLSGLPRE QVLGTGVWLD TTRLRRLLAE KLDIAAQSID AFILGEHGDS 

       190        200        210        220        230        240 
QFPVWSHSSI YGKPVNEYSM EKLGESLDLK LIGETARDTG FEIYHQKGCT EYGIAGTIVE 

       250        260        270        280        290        300 
ICRHIFSGSQ RALTVSCVLD GEYGQTGLAI GVPAVLSQNG VKEIISLKLN EQEQQAFDHS 

       310 
AAVIKENIKS I
Q92BI0 in FASTA format

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