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UniProtKB/Swiss-Prot entry Q92055

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHA_FUNHE
Primary accession number Q92055
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 55)
Name and origin of the protein
Protein name L-lactate dehydrogenase A chain
Synonyms LDH-A
EC 1.1.1.27
LDH-M
Gene name
Name: ldha
From
Fundulus heteroclitus (Killifish) (Mummichog) [TaxID: 8078] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Atherinomorpha; Cyprinodontiformes; Fundulidae; Fundulus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Muscle;
PubMed=7670598 [NCBI, ExPASy, EBI, Israel, Japan]
Quattro J.M., Pollock D.D., Powell M., Woods H.A., Powers D.A.;
"Evolutionary relations among vertebrate muscle-type lactate dehydrogenases.";
Mol. Mar. Biol. Biotechnol. 4:224-231(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L43525; AAA99462.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P00336; 5LDH. [HSSP ENTRY / PDB]
SMR Q92055; 2-332.
ModBase Q92055.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
ProtoNet Q92055.
Phylogenomic databases
HOVERGEN Q92055; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   332  331     L-lactate dehydrogenase A chain. PRO_0000168438
NP_BIND   29    57  29     NAD (By similarity). 
ACT_SITE   193   193        Proton acceptor (By similarity). 
BINDING   99    99        NAD (By similarity). 
BINDING   106   106        Substrate (By similarity). 
BINDING   138   138        NAD or substrate (By similarity). 
BINDING   169   169        Substrate (By similarity). 
BINDING   248   248        Substrate (By similarity). 
Sequence information
Length: 332 AA [This is the length of the unprocessed precursor] Molecular weight: 36334 Da [This is the MW of the unprocessed precursor] CRC64: E518179F537C8D88 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTQEKLISH VMKEEPVGCR NKVTVVGVGM VGMASAISVL LKDLCDELAL VDVMEDKLKG 

        70         80         90        100        110        120 
EAMDLQHGAL FLKTHKIVAD KDYSVTANSK VVVVTAGARQ QEGESRLNLV QRNVNIFKFI 

       130        140        150        160        170        180 
IPNIVKYSPN CILLVVSNPV DILTYVAWKL SGFPRHRVIG SGTNLDSARF RHLMGEKFHL 

       190        200        210        220        230        240 
HPSSCHGWIV GEHGDSSVAV WSGVNIAGVS LQTLNPNMGA DGDSENWKEL HKKVVDGAYE 

       250        260        270        280        290        300 
VIKLKGYTSW AIGMSVADLV ESIVKNLHKV HPVSTLVQGM HGVKDEVFLS IPCVLGNSGL 

       310        320        330 
TDVIHMTLKP EEEKQLVKSA ETLWGVQKEL TL
Q92055 in FASTA format

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