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UniProtKB/Swiss-Prot entry Q91Z53

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GRHPR_MOUSE
Primary accession number Q91Z53
Secondary accession numbers None
Integrated into Swiss-Prot on May 10, 2004
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 52)
Name and origin of the protein
Protein name Glyoxylate reductase/hydroxypyruvate reductase
Synonym EC 1.1.1.79
Gene name
Name: Grhpr
Synonyms: Glxr
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=129/SvEv;
TISSUE=Liver;
Cramer S.D.;
"Identification of the mouse GRHPR cDNA from liver.";
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
 PROTEIN SEQUENCE OF 44-58 AND 303-318, AND MASS SPECTROMETRY.
TISSUE=Hippocampus;
Lubec G., Klug S.;
Submitted (MAR-2007) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY113690; AAM52985.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC010194; AAH10194.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_525028.1; -.
UniGene Mm.196574
3D structure databases
HSSP P36234; 1GDH. [HSSP ENTRY / PDB]
SMR Q91Z53; 5-328.
ModBase Q91Z53.
PTM databases
PhosphoSite Q91Z53; -.
2D gel databases
REPRODUCTION-2DPAGE Q91Z53; -.
Organism-specific databases
MGI MGI:1923488; Grhpr.
Gene expression databases
CleanEx MM_GRHPR; -.
GermOnline ENSMUSG00000035637; Mus musculus.
Ontologies
GO
GO:0030267; Molecular function: glyoxylate reductase (NADP) activity (inferred from electronic annotation from EC).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006139; D-isomer_2_OHA_DHase.
IPR006140; D-isomer_2_OHA_DHase_NAD-bd.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00389; 2-Hacid_dh; 1.
PF02826; 2-Hacid_dh_C; 1.
Pfam graphical view of domain structure.
PROSITE PS00065; D_2_HYDROXYACID_DH_1; FALSE_NEG.
PS00670; D_2_HYDROXYACID_DH_2; FALSE_NEG.
PS00671; D_2_HYDROXYACID_DH_3; 1.
ProtoNet Q91Z53.
Genome annotation databases
Ensembl ENSMUSG00000035637; Mus musculus. [Contig view]
GeneID 76238; -.
KEGG mmu:76238; -.
NMPDR fig|10090.3.peg.9510; -.
Phylogenomic databases
HOGENOM Q91Z53; -.
HOVERGEN Q91Z53; -.
Other
NextBio 344835; -.
SOURCE Grhpr; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   328  328     Glyoxylate reductase/hydroxypyruvate reductase. PRO_0000075945
ACT_SITE   245   245        By similarity. 
ACT_SITE   274   274        By similarity. 
ACT_SITE   293   293        Proton donor (By similarity). 
Sequence information
Length: 328 AA [This is the length of the unprocessed precursor] Molecular weight: 35329 Da [This is the MW of the unprocessed precursor] CRC64: BDEC1ADEC1E18153 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKPARLMKVF VTGPLPAEGR AALAQAADCE VEQWNSDDPI PRKDLEQGVV GAHGLLCRLS 

        70         80         90        100        110        120 
DRVDKKLLDA AGANLRVIST LSVGVDHLAL DEIKKRGIRV GYTPGVLTDA TAELAVSLLL 

       130        140        150        160        170        180 
TTCRRLPEAI EEVKNGGWSS WSPLWMCGYG LSQSTVGIVG LGRIGQAIAR RLKPFGVQRF 

       190        200        210        220        230        240 
LYTGRQPRPQ EAAEFQAEFV PIAQLAAESD FIVVSCSLTP DTMGLCSKDF FQKMKNTAIF 

       250        260        270        280        290        300 
INISRGDVVN QEDLYQALAS GQIAAAGLDV TTPEPLPPSH PLLTLKNCVI LPHIGSATYK 

       310        320 
TRNTMSLLAA NNLLAGLRGE AMPSELKL
Q91Z53 in FASTA format

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