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UniProtKB/Swiss-Prot entry Q6LHK5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO12_PHOPR
Primary accession number Q6LHK5
Secondary accession numbers None
Integrated into Swiss-Prot on December 6, 2005
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 29)
Name and origin of the protein
Protein name NAD-dependent malic enzyme 2
Synonyms NAD-ME 2
EC 1.1.1.38
Gene name
Name: sfcA2
OrderedLocusNames: PBPRB1354
From
Photobacterium profundum (Photobacterium sp. (strain SS9)) [TaxID: 74109] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Photobacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1103341; PubMed=15746425 [NCBI, ExPASy, EBI, Israel, Japan]
Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G.;
"Life at depth: Photobacterium profundum genome sequence and expression analysis.";
Science 307:1459-1461(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR378679; CAG23225.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_133025.1; -.
3D structure databases
ModBase Q6LHK5.
Enzyme and pathway databases
BioCyc PPRO298386:PBPRB1354-MON; -.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from HAMAP).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01619; -; 1.
PBIL [Tree]
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS Q6LHK5.
ProtoNet Q6LHK5.
Genome annotation databases
GeneID 3121452; -.
GenomeReviews CR354532_GR; PBPRB1354.
KEGG ppr:PBPRB1354; -.
NMPDR fig|298386.1.peg.1460; -.
Phylogenomic databases
HOGENOM Q6LHK5; -.
Genome annotation databases
CMR Q6LHK5; PBPRB1354.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   558  558     NAD-dependent malic enzyme 2. PRO_0000160222
ACT_SITE   101   101        Proton donor (By similarity). 
ACT_SITE   172   172        Proton acceptor (By similarity). 
METAL   243   243        Divalent metal cation (By similarity). 
METAL   244   244        Divalent metal cation (By similarity). 
METAL   267   267        Divalent metal cation (By similarity). 
BINDING   154   154        NAD (By similarity). 
BINDING   267   267        NAD (By similarity). 
BINDING   411   411        NAD (By similarity). 
SITE   267   267  1     Important for activity (By similarity). 
Sequence information
Length: 558 AA [This is the length of the unprocessed precursor] Molecular weight: 61562 Da [This is the MW of the unprocessed precursor] CRC64: 19D7E3B15F06EC81 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MYENNKTLYL PYAGPTLLEN ALLNKGSAFS PEERQNFSLM GLLPAAIESI TEQEERAYSQ 

        70         80         90        100        110        120 
YQTFNDDMDK HIYLRNIQDT NETLYYRLID NHIEEMMPII YTPTVGAACE QFSNIYRRGR 

       130        140        150        160        170        180 
GLFLGYPDKG NIVDILNNAA RQDVKIIVIT DGERILGLGD QGIGGMGIPI GKLALYTACG 

       190        200        210        220        230        240 
GINPANTLPI VLDVGTNNTQ LLSDPMYMGW RHPRITGQEY DDFVEEFIQA VKSRWPNALI 

       250        260        270        280        290        300 
QFEDFAQKNA MPLLNRYKDK VCCFNDDIQG TAAVTVGSLL AACKAAGSEL SEQRITFVGA 

       310        320        330        340        350        360 
GSAGCGIAEA IVAQMIAEGL SDSAARARIF MVDRWGLLTD NMQNLLDFQQ KLAQKSATVS 

       370        380        390        400        410        420 
QWNETGNISL LDVVSNGKPT VLIGVPGLFS QEVIMEMHAH CKRPIVLPLS NPTSRVEATP 

       430        440        450        460        470        480 
SDIIRWTEGD ALIATGSPFD PVIFNEKTYP IAQCNNSYIF PGIGLGVLAS GATRVTDEML 

       490        500        510        520        530        540 
MESSRVLAEC SPLAQNGNGA LLPPLKDIHQ VSHCIALAVA KKAVEQNKAP QRTEKQLLEK 

       550 
IESYFWKPEY LKYKRTAL
Q6LHK5 in FASTA format

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