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UniProtKB/Swiss-Prot entry Q5NYA9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH_AZOSE
Primary accession number Q5NYA9
Secondary accession numbers None
Integrated into Swiss-Prot on March 29, 2005
Sequence was last modified on January 4, 2005 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 32)
Name and origin of the protein
Protein name Malate dehydrogenase
Synonym EC 1.1.1.37
Gene name
Name: mdh
OrderedLocusNames: AZOSEA38300
ORFNames: ebA6695
From
Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) [TaxID: 76114] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales; Rhodocyclaceae; Aromatoleum.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1007/s00203-004-0742-9; PubMed=15551059 [NCBI, ExPASy, EBI, Israel, Japan]
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.;
"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1.";
Arch. Microbiol. 183:27-36(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR555306; CAI09955.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_160856.1; -.
3D structure databases
SMR Q5NYA9; 3-328.
ModBase Q5NYA9.
Enzyme and pathway databases
BioCyc ASP76114:EBA6695-MON; -.
Ontologies
GO
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01517; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR010945; Malate_DHase_SF1.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23382; MDH_SF1; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
ProDom PD003052; Mal_dehydrog; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01759; MalateDH-SF1; 1.
PROSITE PS00068; MDH; FALSE_NEG.
BLOCKS Q5NYA9.
ProtoNet Q5NYA9.
Genome annotation databases
GeneID 3181211; -.
GenomeReviews CR555306_GR; AZOSEA38300.
KEGG eba:ebA6695; -.
NMPDR fig|76114.4.peg.3846; -.
Phylogenomic databases
HOGENOM Q5NYA9; -.
Genome annotation databases
CMR Q5NYA9; AZOSEA38300.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   329  329     Malate dehydrogenase. PRO_0000113347
NP_BIND   12    18  7     NAD (By similarity). 
NP_BIND   130   132  3     NAD (By similarity). 
ACT_SITE   191   191        Proton acceptor (By similarity). 
BINDING   93    93        Substrate (By similarity). 
BINDING   99    99        Substrate (By similarity). 
BINDING   106   106        NAD (By similarity). 
BINDING   113   113        NAD (By similarity). 
BINDING   132   132        Substrate (By similarity). 
BINDING   166   166        Substrate (By similarity). 
Sequence information
Length: 329 AA [This is the length of the unprocessed precursor] Molecular weight: 35032 Da [This is the MW of the unprocessed precursor] CRC64: 69EF1CBDC1B3003F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKAPVRVAV TGAAGQIGYS LLFRIASGEM LGKDQPVILQ LLDLPQAQKA VKGVMMELED 

        70         80         90        100        110        120 
CAFPLLAGMV ATDDPNVAFK DADYCLLVGA RPRGPGMERA DLLTANGAIF TVQGKAIAEN 

       130        140        150        160        170        180 
ANENVKVLVV GNPCNTNAYI AGAAARKVGR TNPNNYHGML RLDHNRALSQ LAAKTGRPVS 

       190        200        210        220        230        240 
SLKKMVVWGN HSPTMYADYR FCTSNGDSVK ALVNDHAWNN DVFLPTVGKR GAAIIDARGL 

       250        260        270        280        290        300 
SSAASAANAA IDHMHDWALG SDDWVTMGVP SDGSYGIPAG VVFGVPCECK NGDFKIIQGL 

       310        320 
EIDEYSREKI NKTLGELEDE RAAVADMLK
Q5NYA9 in FASTA format

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