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UniProtKB/Swiss-Prot entry Q5NVR2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDHM_PONAB
Primary accession number Q5NVR2
Secondary accession numbers None
Integrated into Swiss-Prot on May 1, 2007
Sequence was last modified on January 4, 2005 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 27)
Name and origin of the protein
Protein name Malate dehydrogenase, mitochondrial [Precursor]
Synonym EC 1.1.1.37
Gene name
Name: MDH2
From
Pongo abelii (Sumatran orangutan) [TaxID: 9601] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Liver;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR925943; CAI29601.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001127677.1; -.
3D structure databases
SMR Q5NVR2; 24-337.
ModBase Q5NVR2.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR010097; Malate_DHase_NAD-dep_euk_g_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11540:SF1; MDH_euk_g_bac; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
TIGRFAMs TIGR01772; MDH_euk_gproteo; 1.
PROSITE PS00068; MDH; 1.
BLOCKS Q5NVR2.
ProtoNet Q5NVR2.
Genome annotation databases
GeneID 100174759; -.
Phylogenomic databases
HOVERGEN Q5NVR2; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    24  24     Mitochondrion (By similarity). 
CHAIN   25   338  314     Malate dehydrogenase, mitochondrial. PRO_0000285044
NP_BIND   31    37  7     NAD (By similarity). 
NP_BIND   140   142  3     NAD (By similarity). 
ACT_SITE   200   200        Proton acceptor (By similarity). 
BINDING   57    57        NAD (By similarity). 
BINDING   104   104        Substrate (By similarity). 
BINDING   110   110        Substrate (By similarity). 
BINDING   117   117        NAD (By similarity). 
BINDING   142   142        Substrate (By similarity). 
BINDING   176   176        Substrate (By similarity). 
BINDING   251   251        NAD (By similarity). 
MOD_RES   56    56        Phosphotyrosine (By similarity). 
MOD_RES   157   157        N6-acetyllysine (By similarity). 
MOD_RES   239   239        N6-acetyllysine (By similarity). 
MOD_RES   314   314        N6-acetyllysine (By similarity). 
Sequence information
Length: 338 AA [This is the length of the unprocessed precursor] Molecular weight: 35577 Da [This is the MW of the unprocessed precursor] CRC64: 24F1E70F25AD20A4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLSALARPAS AVLRRSFSTS AQNNAKVAVL GASGGIGQPL SLLLKNSPLV SRLTLYDIAH 

        70         80         90        100        110        120 
TPGVAADLSH IETKATVKGY LGPEQLPDCL KGCDVVVIPA GVPRKPGMTR DDLFNTNATI 

       130        140        150        160        170        180 
VATLTSACAQ HCPEAMICVI ANPVNSTIPI TAEVFKKHGV YNPNKIFGVT TLDIVRANTF 

       190        200        210        220        230        240 
VAELKGLDPA RVNVPVIGGH AGKTIIPLIS QCTPKVDFPQ DQLTALTGRI QEAGTEVVKA 

       250        260        270        280        290        300 
KAGAGSATLS MAYAGARFVF SLVDAMNGKE GVVECSFVKS QETECTYFST PLLLGKKGIE 

       310        320        330 
KNLGIGKVSS FEEKMISDAI PELKASIKKG EDFVKTLK
Q5NVR2 in FASTA format

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