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UniProtKB/Swiss-Prot entry Q5LAB4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_BACFN
Primary accession number Q5LAB4
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on June 21, 2005 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 27)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: BF3263
From
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [TaxID: 272559] [HAMAP proteome]
Taxonomy Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1107008; PubMed=15746427 [NCBI, ExPASy, EBI, Israel, Japan]
Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A., Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J.;
"Extensive DNA inversions in the B. fragilis genome control variable gene expression.";
Science 307:1463-1465(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR626927; CAH08959.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_212877.1; -.
3D structure databases
ModBase Q5LAB4.
Enzyme and pathway databases
BioCyc BFRA272559:BF3263-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01033; -; 1.
PBIL [Tree]
InterPro IPR004429; 3-isopropylmalate_DHase.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF13; IPMDH; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00169; leuB; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q5LAB4.
ProtoNet Q5LAB4.
Genome annotation databases
GeneID 3287842; -.
GenomeReviews CR626927_GR; BF3263.
KEGG bfs:BF3263; -.
Phylogenomic databases
HOGENOM Q5LAB4; -.
Genome annotation databases
CMR Q5LAB4; BF3263.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   353  353     3-isopropylmalate dehydrogenase. PRO_0000083645
METAL   219   219        Magnesium or manganese (By similarity). 
METAL   243   243        Magnesium or manganese (By similarity). 
METAL   247   247        Magnesium or manganese (By similarity). 
BINDING   97    97        Substrate (By similarity). 
BINDING   107   107        Substrate (By similarity). 
BINDING   135   135        Substrate (By similarity). 
BINDING   219   219        Substrate (By similarity). 
SITE   142   142  1     Important for catalysis (By similarity). 
SITE   187   187  1     Important for catalysis (By similarity). 
Sequence information
Length: 353 AA [This is the length of the unprocessed precursor] Molecular weight: 39098 Da [This is the MW of the unprocessed precursor] CRC64: 355259EA221F4A84 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDFKIAVLAG DGIGPEISVQ GVEVMSAVCE KFGHKVNYEY AICGADAIDK VGDPFPEETY 

        70         80         90        100        110        120 
RVCKNADAVL FSAVGDPKFD NDPTAKVRPE QGLLAMRKKL GLFANIRPVQ TFKCLVHKSP 

       130        140        150        160        170        180 
LRAELVEGAD FLCIRELTGG MYFGEKYQDN DKAYDTNMYT RPEIERILKV GFEYAMKRRK 

       190        200        210        220        230        240 
HLTVVDKANV LASSRLWRQI AQEMAPQYPE VTTDYMFVDN AAMKMIQEPK FFDVMVTENT 

       250        260        270        280        290        300 
FGDILTDEGS VISGSMGLLP SASTGESTPV FEPIHGSWPQ AKGLNIANPL AQILSVAMLF 

       310        320        330        340        350 
EYFDCKAEGA LIRKAVDASL DANVRTPEIQ VEGGEKFGTK EVGAWIVDYI RKA
Q5LAB4 in FASTA format

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