[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=Tokyo 1998; DOI=10.1038/35024074; PubMed=10993077 [NCBI, ExPASy, EBI, Israel, Japan] Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.; "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."; Nature 407:81-86(2000).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 253-273. DOI=10.1016/0378-1119(94)00910-K; PubMed=7535281 [NCBI, ExPASy, EBI, Israel, Japan] Rouhbakhsh D., Baumann P.; "Characterization of a putative 23S-5S rRNA operon of Buchnera aphidicola (endosymbiont of aphids) unlinked to the 16S rRNA-encoding gene."; Gene 155:107-112(1995).

Comments

CATALYTIC ACTIVITY: Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH.
PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7 .
SIMILARITY: Belongs to the shikimate dehydrogenase family.
SEQUENCE CAUTION:
- Sequence=AAA79125.1; Type=Frameshift; Positions=265;

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000003; BAB13186.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U10496; AAA79125.1; ALT_FRAME; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

I40062; I40062.

RefSeq

NP_240300.1; -.

3D structure databases

HSSP

P15770; 1NYT. [HSSP ENTRY / PDB]

ModBase

Q44607.

Enzyme and pathway databases

BioCyc

BSP107806:BU493-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0050661;	Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0004764;	Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073;	Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

HAMAP

MF_00222; -; 1.
PBIL [Tree]

InterPro

IPR016040; NAD(P)-bd.
IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00507; aroE; 1.

ProtoNet

Q44607.

Genome annotation databases

GeneID

1109836; -.

GenomeReviews

BA000003_GR; BU493.

KEGG

buc:BU493; -.

Phylogenomic databases

HOGENOM

Q44607; -.

Genome annotation databases

CMR

Q44607; BU493.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 273`	`273`	`Shikimate dehydrogenase.`	`PRO_0000135995`
`NP_BIND`	`131 135`	`5`	`NADP (By similarity).`
`ACT_SITE`	`70 70`		`Proton acceptor (Potential).`

Sequence information

Length: 273 AA [This is the length of the unprocessed precursor]

Molecular weight: 31002 Da [This is the MW of the unprocessed precursor]

CRC64: 4EAA9019E77213F9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MFKCKNFNYA VFGNPINHSK SPEIHSLFSK QTGISHFYKS CNVPLNSLYA VLQDFFKKDG 

        70         80         90        100        110        120 
RGANITAPFK QEAYFFCNKL TKRAEVAQSV NTLKKIDNCN ILGDNTDGIG LLSDLIRLNF 

       130        140        150        160        170        180 
IKKNYSILII GAGGAARGVL FPLLSYGCSI CIFNRTVLNA EKLVLQFHKY GNINVFNTNS 

       190        200        210        220        230        240 
LHVKSFDLII NATSHFIQDK DNFIPFSCVS SKTCFYDMNY QTDNTFFFDW SRKTGSNFFS 

       250        260        270 
NGIGMLVFQA AHSFFLWHNV LPEIDYIIDL LNK

Q44607 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools