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UniProtKB/Swiss-Prot entry Q0ABE6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH_ALHEH
Primary accession number Q0ABE6
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on October 17, 2006 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 17)
Name and origin of the protein
Protein name Malate dehydrogenase
Synonym EC 1.1.1.37
Gene name
Name: mdh
OrderedLocusNames: Mlg_0487
From
Alkalilimnicola ehrlichei (strain MLHE-1) [TaxID: 187272] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales; Ectothiorhodospiraceae; Alkalilimnicola.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.;
"Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000453; ABI55841.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_741331.1; -.
3D structure databases
ModBase Q0ABE6.
Ontologies
GO
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01517; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR010945; Malate_DHase_SF1.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23382; MDH_SF1; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
ProDom PD003052; Mal_dehydrog; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01759; MalateDH-SF1; 1.
PROSITE PS00068; MDH; 1.
BLOCKS Q0ABE6.
ProtoNet Q0ABE6.
Genome annotation databases
GeneID 4268355; -.
GenomeReviews CP000453_GR; Mlg_0487.
KEGG aeh:Mlg_0487; -.
NMPDR fig|187272.6.peg.463; -.
Phylogenomic databases
HOGENOM Q0ABE6; -.
Genome annotation databases
CMR Q0ABE6; Mlg_0487.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   326  326     Malate dehydrogenase. PRO_0000294373
NP_BIND   11    17  7     NAD (By similarity). 
NP_BIND   129   131  3     NAD (By similarity). 
ACT_SITE   187   187        Proton acceptor (By similarity). 
BINDING   92    92        Substrate (By similarity). 
BINDING   98    98        Substrate (By similarity). 
BINDING   105   105        NAD (By similarity). 
BINDING   112   112        NAD (By similarity). 
BINDING   131   131        Substrate (By similarity). 
BINDING   162   162        Substrate (By similarity). 
Sequence information
Length: 326 AA [This is the length of the unprocessed precursor] Molecular weight: 35215 Da [This is the MW of the unprocessed precursor] CRC64: DD57E732A2A295B7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKAPVRVAVT GAAGQIGYSL LFRIASGDML GKDQPVILQL LEITPALEAL KGVVMELEDC 

        70         80         90        100        110        120 
AFPLVSGITT SDKAEEAFKD ADIALLVGAR PRGPGMERKD LLEANAAIFS AQGKALNDAA 

       130        140        150        160        170        180 
SRDVKVLVVG NPANTNSLIA QRNAPDLDPR NFTAMTRLDH NRAVAQLANK TGAHNTEIKN 

       190        200        210        220        230        240 
MIIWGNHSAT QYPDISKTKV KGEAAPGLVE RDWYENDFIP TVQQRGAAII KARGASSAAS 

       250        260        270        280        290        300 
AASSAIDHIR DWVLGTPEGE WTSMAVPSDG SYGIEKGIIY SYPCVCRNGD YEIVQDLEID 

       310        320 
EFSREKMQAT EKELVEERDA VEHLLP
Q0ABE6 in FASTA format

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