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UniProtKB/Swiss-Prot entry Q07993


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name XYL2_YEAST
Primary accession number Q07993
Secondary accession numbers None
Integrated into Swiss-Prot on January 9, 2007
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 51)
Name and origin of the protein
Protein name D-xylulose reductase
Synonyms EC 1.1.1.9
Xylitol dehydrogenase
XDH
Gene name
Name: XYL2
OrderedLocusNames: YLR070C
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204511 / S288c / AB972;
PubMed=9169871 [NCBI, ExPASy, EBI, Israel, Japan]
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
Nature 387:87-90(1997).
[2]
INDUCTION, AND BIOPHYSICOCHEMICAL PROPERTIES.
DOI=10.1016/S0014-5793(99)01016-9; PubMed=10486580 [NCBI, ExPASy, EBI, Israel, Japan]
Richard P., Toivari M.H., Penttilae M.;
"Evidence that the gene YLR070c of Saccharomyces cerevisiae encodes a xylitol dehydrogenase.";
FEBS Lett. 457:135-138(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z73242; CAA97627.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S64902; S64902.
RefSeq NP_013171.1; -.
3D structure databases
HSSP Q00796; 1PL7. [HSSP ENTRY / PDB]
ModBase Q07993.
Protein-protein interaction databases
DIP DIP:4533N; -.
IntAct Q07993; -.
Organism-specific databases
CYGD YLR070c; -.
SGD S000004060; XYL2.
Yeast-GFP YLR070C.
Ontologies
GO
GO:0046526; Molecular function: D-xylulose reductase activity (inferred from direct assay from SGD).
GO:0005999; Biological process: xylulose biosynthetic process (inferred from direct assay from SGD).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
ProDom PD040557; GroES_related; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00059; ADH_ZINC; 1.
BLOCKS Q07993.
ProtoNet Q07993.
Genome annotation databases
Ensembl YLR070C; Saccharomyces cerevisiae. [Contig view]
GeneID 850759; -.
GenomeReviews Y13138_GR; YLR070C.
KEGG sce:YLR070C; -.
NMPDR fig|4932.3.peg.4162; -.
Phylogenomic databases
HOGENOM Q07993; -.
Other
LinkHub Q07993; -.
NextBio 966906; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Complete proteome; Metal-binding; NAD; Oxidoreductase; Xylose metabolism; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   356  356     D-xylulose reductase. PRO_0000270925
NP_BIND   179   184  6     NAD (Potential). 
METAL   44    44        Zinc; catalytic (By similarity). 
METAL   69    69        Zinc; catalytic (By similarity). 
METAL   155   155        Zinc; catalytic (By similarity). 
Sequence information
Length: 356 AA [This is the length of the unprocessed precursor] Molecular weight: 38600 Da [This is the MW of the unprocessed precursor] CRC64: 5DFD19BDB2E0AE00 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTDLTTQEAI VLERPGKITL TNVSIPKISD PNEVIIQIKA TGICGSDIHY YTHGRIANYV 

        70         80         90        100        110        120 
VESPMVLGHE SSGIVALIGE NVKTLKVGDR VALEPGIPDR FSPEMKEGRY NLDPNLKFAA 

       130        140        150        160        170        180 
TPPFDGTLTK YYKTMKDFVY KLPDDVSFEE GALIEPLSVA IHANKLAKIK FGARCVVFGA 

       190        200        210        220        230        240 
GPIGLLAGKV ASVFGAADVV FVDLLENKLE TARQFGATHI VNSGDLPHGV TVDSVIKKAI 

       250        260        270        280        290        300 
GKKGADVVFE CSGAEPCVRA GIEVCKAGGT IVQVGMGQEE IQFPISIIPT KELTFQGCFR 

       310        320        330        340        350 
YCQGDYSDSI ELVSSRKLSL KPFITHRYSF KDAVEAFEET SHHPLNNIKT IIEGPE 

Q07993 in FASTA format

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