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UniProtKB/Swiss-Prot entry Q04820

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDHC_ECHGR
Primary accession number Q04820
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on December 15, 1998 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 63)
Name and origin of the protein
Protein name Malate dehydrogenase, cytoplasmic
Synonym EC 1.1.1.37
Gene name
Name: MDH
From
Echinococcus granulosus [TaxID: 6210] 
Taxonomy Eukaryota; Metazoa; Platyhelminthes; Cestoda; Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0166-6851(93)90040-5; PubMed=8366891 [NCBI, ExPASy, EBI, Israel, Japan]
Rodrigues J.J., Ferreira H.B., Zaha A.;
"Molecular cloning and characterization of an Echinococcus granulosus cDNA encoding malate dehydrogenase.";
Mol. Biochem. Parasitol. 60:157-160(1993).
[2]
 SEQUENCE REVISION.
Rodrigues J.J.;
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L08894; AAC28239.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T09228; T09228.
3D structure databases
HSSP P11708; 4MDH. [HSSP ENTRY / PDB]
ModBase Q04820.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR011274; Malate_DHase_NAD-dep_euk.
IPR010945; Malate_DHase_SF1.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23382; MDH_SF1; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
ProDom PD003052; Mal_dehydrog; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01759; MalateDH-SF1; 1.
TIGR01758; MDH_euk_cyt; 1.
PROSITE PS00068; MDH; 1.
BLOCKS Q04820.
ProtoNet Q04820.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   332  332     Malate dehydrogenase, cytoplasmic. PRO_0000113408
NP_BIND   11    17  7     NAD (By similarity). 
NP_BIND   129   131  3     NAD (By similarity). 
ACT_SITE   187   187        Proton acceptor (By similarity). 
BINDING   92    92        Substrate (By similarity). 
BINDING   98    98        Substrate (By similarity). 
BINDING   105   105        NAD (By similarity). 
BINDING   112   112        NAD (By similarity). 
BINDING   131   131        Substrate (By similarity). 
BINDING   162   162        Substrate (By similarity). 
Sequence information
Length: 332 AA [This is the length of the unprocessed precursor] Molecular weight: 36651 Da [This is the MW of the unprocessed precursor] CRC64: 0EACE29A26F565E2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPGPLRVLIT GAAGQIAYNL SNMVANGNLF GKDQQIILHL LDIPEAKTVL DGVVMELQDC 

        70         80         90        100        110        120 
AFTVLAGIVP THCLKEAFTD IDVALMVGAM PRKQGMERRD LLSSNVKIFK EQGEALDKYA 

       130        140        150        160        170        180 
KKTVKVLVVG NPANTNCLIM SKYAPSIPKE NFTALTRLDH NRAIYQVAAK AGVPNTCVKN 

       190        200        210        220        230        240 
VCIWGNHSNK QFPDLSHAVV TKDGKQHPAK ELINDEKWVK EVFIPCVQNR GAAVIGLRKL 

       250        260        270        280        290        300 
SRAASAAKAI VDQMRDWWFG TKEGEWVSMS VYSTGDHYGA PKDIYFSFPV TIKDGHYKVV 

       310        320        330 
DGLSMDEWSR SLFNLSADEL VDEREVALAS FK
Q04820 in FASTA format

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