NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=VTT-E-74023;
PubMed=8444801 [NCBI, ExPASy, EBI, Israel, Japan]
Blomqvist K., Nikkola M., Lehtovaara P., Suihko M.-L., Airaksinen U., Straby K.B., Knowles J.K.C., Penttilae M.E.;
"Characterization of the genes of the 2,3-butanediol operons from Klebsiella terrigena and Enterobacter aerogenes.";
J. Bacteriol. 175:1392-1404(1993).

Comments

FUNCTION: Catalyzes the reversible reduction of acetoin to 2,3-butanediol in the presence of NADH.
CATALYTIC ACTIVITY: Acetoin + NAD⁺ = diacetyl + NADH.
SUBUNIT: Homotetramer.
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L04507; AAA25056.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

E47069; E47069.

3D structure databases

HSSP

Q48436; 1GEG. [HSSP ENTRY / PDB]

SMR

Q04520; 1-228.

ModBase

Q04520.

Ontologies

GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR014007; 23BDH.
IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

TIGRFAMs

TIGR02415; 23BDH; 1.

PROSITE

PS00061; ADH_SHORT; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 241`	`241`	`Acetoin(diacetyl) reductase.`	`PRO_0000054538`
`NP_BIND`	`6 30`	`25`	`NAD (By similarity).`
`ACT_SITE`	`152 152`		`Proton acceptor (By similarity).`
`ACT_SITE`	`156 156`		`By similarity.`
`BINDING`	`139 139`		`Substrate (By similarity).`

Sequence information

Length: 241 AA [This is the length of the unprocessed precursor]

Molecular weight: 25313 Da [This is the MW of the unprocessed precursor]

CRC64: D85801C56931BF04 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MQKVALVTGA GQGIGKAIAL RLVKDGFAVA IADYNDATAT AVAAEINQAG GRAVAIKVDV 

        70         80         90        100        110        120 
SRRDQVFAAV EQARKALGGF NVIVNNAGIA PSTPIESITE EIVDRVYNIN VKGVIWGMQA 

       130        140        150        160        170        180 
AVEAFKKEGH GGKIVNACSQ AGHVGNPELA VYSSSKFAVR GLTQTAARDL APLGITVNGF 

       190        200        210        220        230        240 
CPGIVKTPMW AEIDRQCRKR RANRWATARL NLPNASPLAA CRSLKTSPPA CRSSPARIPT 


I

Q04520 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools