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UniProtKB/Swiss-Prot entry Q03505

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH1_RABIT
Primary accession number Q03505
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 58)
Name and origin of the protein
Protein name Alcohol dehydrogenase 1
Synonyms EC 1.1.1.1
Alcohol dehydrogenase subunit alpha
Gene name
Name: ADH1
From
Oryctolagus cuniculus (Rabbit) [TaxID: 9986] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Liver;
DOI=10.1111/j.1432-1033.1993.tb17731.x; PubMed=8477702 [NCBI, ExPASy, EBI, Israel, Japan]
Hoeoeg J.-O., Vagelopoulos N., Yip P.-K., Keung W.M., Joernvall H.;
"Isozyme developments in mammalian class-I alcohol dehydrogenase. cDNA cloning, functional correlations, and lack of evidence for genetic isozymes in rabbit.";
Eur. J. Biochem. 213:31-38(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X69799; CAA49458.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S30353; S29343.
RefSeq NP_001095174.1; -.
UniGene Ocu.3250
3D structure databases
HSSP P00326; 1HT0. [HSSP ENTRY / PDB]
SMR Q03505; 2-375.
ModBase Q03505.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
BLOCKS Q03505.
ProtoNet Q03505.
Genome annotation databases
GeneID 100009283; -.
Phylogenomic databases
HOVERGEN Q03505; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Direct protein sequencing; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   375  374     Alcohol dehydrogenase 1. PRO_0000160668
METAL   47    47        Zinc 1; catalytic (By similarity). 
METAL   68    68        Zinc 1; catalytic (By similarity). 
METAL   98    98        Zinc 2 (By similarity). 
METAL   101   101        Zinc 2 (By similarity). 
METAL   104   104        Zinc 2 (By similarity). 
METAL   112   112        Zinc 2 (By similarity). 
METAL   175   175        Zinc 1; catalytic (By similarity). 
Sequence information
Length: 375 AA [This is the length of the unprocessed precursor] Molecular weight: 39588 Da [This is the MW of the unprocessed precursor] CRC64: 47F03877C54E5B69 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTAGKVIKC KAAVLWQLNK PFSIEEVEVA PPKAHEVRIK MVATGICRSD DHAVTGSIAV 

        70         80         90        100        110        120 
PLPVILGHEA AGIVESIGEG VTTVKPGDKV IPLFTPQCGK CRICKHPESN FCLINDLGKP 

       130        140        150        160        170        180 
KGMLLDGTSR FTCKGKPIHH FIGTSTFSQY TVVDEIAVAK IDAAAPLEKV CLIGCGFSTG 

       190        200        210        220        230        240 
YGSAVKVAKV TPGSTCAVFG LGGVGLSVIM GCKAAGASRI IAVDINKDKF PKAKEVGATE 

       250        260        270        280        290        300 
CINPQDYKKP IQEVIQEISD GGVDFSFEVI GRLDTVVAAL LSCHGACGTS VIVGVPPDSQ 

       310        320        330        340        350        360 
SLTVNPMLLL SGRTWKGAIF GGFKSKDSVP KLVADFMAKK FSLDPLITNV LPFEKINEGF 

       370 
DLLRSGKSIR TILTF
Q03505 in FASTA format

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