[1]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=8504807 [NCBI, ExPASy, EBI, Israel, Japan] Niimi T., Yamashita O., Yaginuma T.; "A cold-inducible Bombyx gene encoding a protein similar to mammalian sorbitol dehydrogenase. Yolk nuclei-dependent gene expression in diapause eggs."; Eur. J. Biochem. 213:1125-1131(1993).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Tokai X Asahi; TISSUE=Fat body; PubMed=8933178 [NCBI, ExPASy, EBI, Israel, Japan] Niimi T., Yamashita O., Yaginuma T.; "Structure of the Bombyx sorbitol dehydrogenase gene: a possible alternative use of the promoter."; Insect Mol. Biol. 5:269-280(1996).

Comments

CATALYTIC ACTIVITY: L-iditol + NAD⁺ = L-sorbose + NADH.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
SUBUNIT: Homotetramer (By similarity).
INDUCTION: By cold.
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D13371; BAA02634.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
D66906; BAA11030.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S32484; S32484.

NP_001037311.1; -.

3D structure databases

HSSP

O96496; 1E3J. [HSSP ENTRY / PDB]

ModBase

Q02912.

Ontologies

GO:0003939;	Molecular function: L-iditol 2-dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006950;	Biological process: response to stress (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
IPR001100; Pyr_nuc-diS_OxRdtase.
Graphical view of domain structure.

PANTHER

PTHR11695; ADH_Sf_Zn; 1.

Pfam

PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.

PRINTS

PR00411; PNDRDTASEI.

ProDom

PD040557; GroES_related; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00059; ADH_ZINC; 1.

Genome annotation databases

GeneID

692742; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Metal-binding; NAD; Oxidoreductase; Stress response; Zinc.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 348`	`348`	`Sorbitol dehydrogenase.`	`PRO_0000160820`
`METAL`	`40 40`		`Zinc; catalytic (By similarity).`
`METAL`	`65 65`		`Zinc; catalytic (By similarity).`
`METAL`	`66 66`		`Zinc; catalytic (By similarity).`

Sequence information

Length: 348 AA [This is the length of the unprocessed precursor]

Molecular weight: 37158 Da [This is the MW of the unprocessed precursor]

CRC64: 2985304E9ADE6FF0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTENYAAVLH GANDVRIEKI PVPEINDDEV LIKIDCVGIC GSDVKLYSTG TCGADVIDKP 

        70         80         90        100        110        120 
IVIGHEGAGT VVKVGDKVSS LRVGDRVAIE PTQPCRSCEL CKRGKYNLCV EPRYCSSMGA 

       130        140        150        160        170        180 
PGNLCRYYKH VADFCHKLPD NLTMEEGAAV QPLAIVIHAC NRAKITLGSK IVILGAGPIG 

       190        200        210        220        230        240 
ILCAMSAKAM GASKIILTDV VQSRLDAALE LGADNVLLVR REYTDEEVVE KIVKLLGDRP 

       250        260        270        280        290        300 
DVSIDACGYG SAQRVALLVT KTAGLVLVVG IADKTVELPL SQALLREVDV VGSFRIMNTY 

       310        320        330        340 
QPALAAVSSG AIPLDKFITH RFPLNKTKEA LDLAKSGAAM KILIHVQN

Q02912 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools