NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
STRAIN=ATCC 24725 / CBS 481.73 / CCRC 36200 / NRRL 6361 / VKM-F-1767;
PubMed=7961751 [NCBI, ExPASy, EBI, Israel, Japan]
Reiser J., Muheim A., Hardegger M., Frank G., Fiechter A.;
"Aryl-alcohol dehydrogenase from the white-rot fungus Phanerochaete chrysosporium. Gene cloning, sequence analysis, expression, and purification of the recombinant enzyme.";
J. Biol. Chem. 269:28152-28159(1994).

Comments

CATALYTIC ACTIVITY: An aromatic alcohol + NADP⁺ = an aromatic aldehyde + NADPH.
PTM: The N-terminus is blocked.
SIMILARITY: Belongs to the aldo/keto reductase 2 family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L08964; AAA61931.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A55449; A55449.

3D structure databases

ModBase

Q01752.

Ontologies

GO:0047681;	Molecular function: aryl-alcohol dehydrogenase (NADP+) activity (inferred from electronic annotation from EC).
GO:0019439;	Biological process: aromatic compound catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001395; Aldo/ket_red.
Graphical view of domain structure.

PANTHER

PTHR11732; Aldo/ket_red; 1.

Pfam

PF00248; Aldo_ket_red; 1.
Pfam graphical view of domain structure.

ProDom

PD000288; Aldo/ket_red; 1.
[Domain structure / List of seq. sharing at least 1 domain]

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Aromatic hydrocarbons catabolism; Direct protein sequencing; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 385`	`385`	`Aryl-alcohol dehydrogenase [NADP+].`	`PRO_0000070364`
`NP_BIND`	`238 248`	`11`	`NADP (By similarity).`
`ACT_SITE`	`76 76`		`Proton donor (By similarity).`

Sequence information

Length: 385 AA [This is the length of the unprocessed precursor]

Molecular weight: 43563 Da [This is the MW of the unprocessed precursor]

CRC64: 7D5D6E00690B9A20 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNIWAPAPEP PTKLGRHRQL APGCGLHVSP IQLGAMSIGD KWHPYGMGTM DKEASFKLLD 

        70         80         90        100        110        120 
AFYNAGGNFI DTANVYQDET SEEFIGEWME ARGNRDQMVV ATKYSLVYKR GASFEEIPQK 

       130        140        150        160        170        180 
TQYVGNSLKS MHISVHDSLR KLRTSYIDIF YVHFWDYTCT IEEVMNGLHN LVAQGKVLYL 

       190        200        210        220        230        240 
GVSDTPAWVV SKANNYARMA GKTPFVIYEG EWNITMRDME RDIIPMCIHE GMAIAPWNVL 

       250        260        270        280        290        300 
CAGKIRTDAE EERRLKSGEG GRTLLQFDGW LRNETERKVS KALEKVAEEI GAKSITSVAI 

       310        320        330        340        350        360 
AYLMQKFPYV FPIVGGRKVE HLYANLEALD ISLSPEQMQF LNDTVPFNKG FPYLLFGDGS 

       370        380 
DYNIVHKAAG HYDKWPAQQA IRPQK

Q01752 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools