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UniProtKB/Swiss-Prot entry Q00612


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PD1_MOUSE
Primary accession number Q00612
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1993
Sequence was last modified on March 20, 2007 (Sequence version 3)
Annotations were last modified on    November 4, 2008 (Entry version 80)
Name and origin of the protein
Protein name Glucose-6-phosphate 1-dehydrogenase X
Synonyms G6PD
EC 1.1.1.49
Gene name
Name: G6pdx
Synonyms: G6pd, G6pd-1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8400362 [NCBI, ExPASy, EBI, Israel, Japan]
Zollo M.Z., D'Urso M., Schlessinger D., Chen E.Y.;
"Sequence of mouse glucose-6-phosphate dehydrogenase cDNA.";
DNA Seq. 3:319-322(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=NOD;
TISSUE=Thymus;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40.
STRAIN=BALB/c;
DOI=10.1016/0378-1119(91)90078-P; PubMed=1874446 [NCBI, ExPASy, EBI, Israel, Japan]
Toniolo D., Filippi M., Dono R., Lettieri T., Martini G.;
"The CpG island in the 5' region of the G6PD gene of man and mouse.";
Gene 102:197-203(1991).
[4]
PROTEIN SEQUENCE OF 57-71; 175-191 AND 247-257, AND MASS SPECTROMETRY.
TISSUE=Brain, and Hippocampus;
Lubec G., Klug S., Yang J.W., Zigmond M.;
Submitted (JUL-2007) to UniProtKB.
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 163-214 AND 352-454.
STRAIN=BALB/c;
DOI=10.1016/S0027-5107(97)00109-7; PubMed=9330624 [NCBI, ExPASy, EBI, Israel, Japan]
Kuraguchi M., Thomas G.A., Williams E.D.;
"Somatic mutation of the glucose-6-phosphate dehydrogenase (g6pd) gene in colonic stem cells and crypt restricted loss of G6PD activity.";
Mutat. Res. 379:69-75(1997).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-507, AND MASS SPECTROMETRY.
TISSUE=Mast cell;
PubMed=17947660 [NCBI, ExPASy, EBI, Israel, Japan]
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.;
"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.";
J. Immunol. 179:5864-5876(2007).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-401; TYR-503 AND TYR-507, AND MASS SPECTROMETRY.
TISSUE=Brain;
DOI=10.1021/pr0701254; PubMed=18034455 [NCBI, ExPASy, EBI, Israel, Japan]
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.";
J. Proteome Res. 7:311-318(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z11911; CAA77967.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK088135; BAC40166.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X53617; CAA37679.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U88533; AAB52998.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U88534; AAB52999.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A56686; A56686.
RefSeq NP_032088.1; -.
UniGene Mm.27210
3D structure databases
HSSP P11413; 1QKI. [HSSP ENTRY / PDB]
SMR Q00612; 28-515.
ModBase Q00612.
Protein-protein interaction databases
IntAct Q00612; -.
PTM databases
PhosphoSite Q00612; -.
2D gel databases
REPRODUCTION-2DPAGE Q00612; -.
Organism-specific databases
MGI MGI:105979; G6pdx.
Gene expression databases
ArrayExpress Q00612; -.
CleanEx MM_G6PDX; -.
GermOnline ENSMUSG00000031400; Mus musculus.
Ontologies
GO
GO:0004345; Molecular function: glucose-6-phosphate dehydrogenase activity (inferred from direct assay from MGI).
GO:0042803; Molecular function: protein homodimerization activity (inferred from physical interaction from MGI).
GO:0001998; Biological process: angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure (inferred from mutant phenotype from MGI).
GO:0048821; Biological process: erythrocyte development (inferred from mutant phenotype from MGI).
GO:0006749; Biological process: glutathione metabolic process (inferred from mutant phenotype from MGI).
GO:0032613; Biological process: interleukin-10 production (inferred from mutant phenotype from MGI).
GO:0032615; Biological process: interleukin-12 production (inferred from mutant phenotype from MGI).
GO:0006741; Biological process: NADP biosynthetic process (inferred from direct assay from MGI).
GO:0019322; Biological process: pentose biosynthetic process (inferred from direct assay from MGI).
GO:0040014; Biological process: regulation of multicellular organism growth (inferred from mutant phenotype from MGI).
GO:0006979; Biological process: response to oxidative stress (inferred from mutant phenotype from MGI).
GO:0002033; Biological process: vasodilation by angiotensin involved in regulation of systemic arterial blood pressure (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000110; G6PD; 1.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00871; zwf; 1.
PROSITE PS00069; G6P_DEHYDROGENASE; 1.
BLOCKS Q00612.
ProtoNet Q00612.
Genome annotation databases
Ensembl ENSMUSG00000031400; Mus musculus. [Contig view]
GeneID 14381; -.
KEGG mmu:14381; -.
Phylogenomic databases
HOGENOM Q00612; -.
HOVERGEN Q00612; -.
Other
NextBio 285893; -.
SOURCE G6pdx; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Carbohydrate metabolism; Direct protein sequencing; Glucose metabolism; NADP; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   515  514     Glucose-6-phosphate 1-dehydrogenase X. PRO_0000068085
ACT_SITE   263   263        Proton acceptor (By similarity). 
BINDING   40    40        NADP (By similarity). 
BINDING   72    72        NADP (By similarity). 
BINDING   201   201        Substrate (By similarity). 
BINDING   205   205        Substrate (By similarity). 
BINDING   238   238        NADP (By similarity). 
BINDING   357   357        NADP (By similarity). 
BINDING   487   487        NADP (By similarity). 
MOD_RES   2     2        N-acetylalanine (By similarity). 
MOD_RES   401   401        Phosphotyrosine. 
MOD_RES   503   503        Phosphotyrosine. 
MOD_RES   507   507        Phosphotyrosine. 
CONFLICT   24    24        D -> Y (in Ref. 3; CAA37679). 
Sequence information
Length: 515 AA [This is the length of the unprocessed precursor] Molecular weight: 59263 Da [This is the MW of the unprocessed precursor] CRC64: C8AF0D4099B7AEC3 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAEQVALSRT QVCGILREEL YQGDAFHQAD THIFIIMGAS GDLAKKKIYP TIWWLFRDGL 

        70         80         90        100        110        120 
LPEDTFIVGY ARSRLTVDDI RKQSEPFFKA TPEERPKLEE FFARNSYVAG QYDDAASYKH 

       130        140        150        160        170        180 
LNSHMNALHQ GMQANRLFYL ALPPTVYEAV TKNIQETCMS QTGWNRIIVE KPFGRDLQSS 

       190        200        210        220        230        240 
NQLSNHISSL FREDQIYRID HYLGKEMVQN LMVLRFANRI FGPIWNRDNI ACVILTFKEP 

       250        260        270        280        290        300 
FGTEGRGGYF DEFGIIRDVM QNHLLQMLCL VAMEKPATTG SDDVRDEKVK VLKCISEVET 

       310        320        330        340        350        360 
DNVVLGQYVG NPNGEGEAAN GYLDDPTVPH GSTTATFAAA VLYVENERWD GVPFILRCGK 

       370        380        390        400        410        420 
ALNERKAEVR LQFRDVAGDI FHQQCKRNEL VIRVQPNEAV YTKMMTKKPG MFFNPEESEL 

       430        440        450        460        470        480 
DLTYGNRYKN VKLPDAYERL ILDVFCGSQM HFVRSDELRE AWRIFTPLLH KIDREKPQPI 

       490        500        510 
PYVYGSRGPT EADELMKRVG FQYEGTYKWV NPHKL 

Q00612 in FASTA format

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View entry in raw text format (no links)
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