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UniProtKB/Swiss-Prot entry P90593

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GPDA_TRYBB
Primary accession number P90593
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on May 1, 1997 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 50)
Name and origin of the protein
Protein name Glycerol-3-phosphate dehydrogenase [NAD+], glycosomal
Synonym EC 1.1.1.8
Gene name
Name: GPD
From
Trypanosoma brucei brucei [TaxID: 5702] 
Taxonomy Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=427;
DOI=10.1016/0166-6851(95)02556-1; PubMed=8920004 [NCBI, ExPASy, EBI, Israel, Japan]
Kohl L., Drmota T., Thi C.-D., Callens M., van Beeumen J., Opperdoes F.R., Michels P.A.M.;
"Cloning and characterization of the NAD-linked glycerol-3-phosphate dehydrogenases of Trypanosoma brucei brucei and Leishmania mexicana mexicana and expression of the trypanosome enzyme in Escherichia coli.";
Mol. Biochem. Parasitol. 76:159-173(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X89738; CAA61890.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T48649; T48649.
3D structure databases
HSSP P90551; 1EVY. [HSSP ENTRY / PDB]
ModBase P90593.
Ontologies
GO
GO:0020015; Cellular component: glycosome (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013328; DHase_multihelical.
IPR016040; NAD(P)-bd.
IPR017751; NAD-dep_Gly3P_DH_euk.
IPR006168; NAD-dep_Gly3P_DHase.
IPR011128; NAD-dep_Gly3P_DHase_N.
IPR006109; NAD_Gly3P_DHase_C.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
PANTHER PTHR11728; NAD_Gly3P_DH; 1.
Pfam PF07479; NAD_Gly3P_dh_C; 1.
PF01210; NAD_Gly3P_dh_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000114; Glycerol-3-P_dh; 1.
PRINTS PR00077; GPDHDRGNASE.
ProDom PD001278; NAD_Gly3P_C; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00957; NAD_G3PDH; 1.
BLOCKS P90593.
ProtoNet P90593.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycosome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   354  354     Glycerol-3-phosphate dehydrogenase [NAD+], glycosomal. PRO_0000138083
NP_BIND   15    20  6     NAD (By similarity). 
REGION   267   268  2     Substrate binding (By similarity). 
MOTIF   352   354  3     Microbody targeting signal (Potential). 
ACT_SITE   203   203        Proton acceptor (By similarity). 
BINDING   90    90        NAD (By similarity). 
BINDING   118   118        NAD; via amide nitrogen (By similarity). 
BINDING   118   118        Substrate (By similarity). 
BINDING   150   150        NAD; via amide nitrogen (By similarity). 
BINDING   267   267        NAD (By similarity). 
BINDING   293   293        NAD (By similarity). 
Sequence information
Length: 354 AA [This is the length of the unprocessed precursor] Molecular weight: 37783 Da [This is the MW of the unprocessed precursor] CRC64: 12CE19AEDA9E4EC9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MVSGVTYLKR GAVFGSGAFG TALACVLAKK CESVSVWHMN ANEARVVNQK HENVYFLPGA 

        70         80         90        100        110        120 
PLPANLTFTA DAEECAKGAE IVLFVIPTQF LRGFLQKNSH ILRNHVVSRN VPVVMCSKGI 

       130        140        150        160        170        180 
ERSSLLFPAQ ILEEFLPNYP IGVIAGPSFA IEVAKGMLTN VCTAAADINM ARKIQRIMTT 

       190        200        210        220        230        240 
SDGSFRCWAT TDVIGCEIAS AMKNVLAIAS GALKGLGTEN NARAALISRG LLEIRDLTLA 

       250        260        270        280        290        300 
LGGTGEAVFG LPGLGDLLLT CSSELSRNFT VGMKLGQGIS LEEIKRTSKA VAEGVATAEP 

       310        320        330        340        350 
LERLAKKHNA DLPICHEVYN VLYANGCAKR SFKKLNSCKL ADEGLPALPR TSKM
P90593 in FASTA format

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