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UniProtKB/Swiss-Prot entry P78812


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 6PGD_SCHPO
Primary accession number P78812
Secondary accession number Q9UQW5
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on January 11, 2001 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 63)
Name and origin of the protein
Protein name 6-phosphogluconate dehydrogenase, decarboxylating
Synonym EC 1.1.1.44
Gene name
ORFNames: SPBC660.16
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=PR745;
DOI=10.1093/dnares/4.6.363; PubMed=9501991 [NCBI, ExPASy, EBI, Israel, Japan]
Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
"Identification of open reading frames in Schizosaccharomyces pombe cDNAs.";
DNA Res. 4:363-369(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107 AND SER-215, AND MASS SPECTROMETRY.
DOI=10.1021/pr7006335; PubMed=18257517 [NCBI, ExPASy, EBI, Israel, Japan]
Wilson-Grady J.T., Villen J., Gygi S.P.;
"Phosphoproteome analysis of fission yeast.";
J. Proteome Res. 7:1088-1097(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D89161; BAA13823.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CU329671; CAA22536.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T40628; T40628.
T42523; T42523.
RefSeq NP_595095.1; -.
3D structure databases
HSSP P00349; 2PGD. [HSSP ENTRY / PDB]
ModBase P78812.
Enzyme and pathway databases
BioCyc SPOM-XXX-01:SPOM-XXX-01-003196-MON; -.
Organism-specific databases
GeneDB_Spombe SPBC660.16; -.
Gene expression databases
ArrayExpress P78812; -.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from GeneDB_SPombe).
GO:0050661; Molecular function: NADP binding (inferred from direct assay from GeneDB_SPombe).
GO:0004616; Molecular function: phosphogluconate dehydrogenase (decarboxylating) activity (inferred from direct assay from GeneDB_SPombe).
GO:0033554; Biological process: cellular response to stress (inferred from expression pattern from GeneDB_SPombe).
GO:0009051; Biological process: pentose-phosphate shunt, oxidative branch (inferred from direct assay from GeneDB_SPombe).
QuickGo view.
Family and domain databases
InterPro IPR006183; 6-phosphogluconate_DHase.
IPR006114; 6PGDH_C.
IPR006113; 6PGDH_decarbox.
IPR006115; 6PGDH_NAD-bd.
IPR006184; 6PGdom_BS.
IPR013328; DHase_multihelical.
IPR012284; Fibritin/6PGD_C-extension.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
Pfam PF00393; 6PGD; 1.
PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00076; 6PGDHDRGNASE.
TIGRFAMs TIGR00873; gnd; 1.
PROSITE PS00461; 6PGD; 1.
BLOCKS P78812.
ProtoNet P78812.
Genome annotation databases
GeneID 2541146; -.
KEGG spo:SPBC660.16; -.
NMPDR fig|4896.1.peg.961; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase; Pentose shunt; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   492  492     6-phosphogluconate dehydrogenase, decarboxylating. PRO_0000090074
MOD_RES   107   107        Phosphoserine. 
MOD_RES   215   215        Phosphoserine. 
CONFLICT   219   220        IA -> ST (in Ref. 1; BAA13823). 
Sequence information
Length: 492 AA [This is the length of the unprocessed precursor] Molecular weight: 53680 Da [This is the MW of the unprocessed precursor] CRC64: F55F342957A9D3E1 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSQKEVADFG LIGLAVMGQN LILNGADKGF TVCCYNRTTS RVDEFLANEA KGKSIVGAHS 

        70         80         90        100        110        120 
LEEFVSKLKK PRVCILLVKA GKPVDYLIEG LAPLLEKGDI IVDGGNSHYP DTTRRCEELA 

       130        140        150        160        170        180 
KKGILFVGSG VSGGEEGARY GPSLMPGGNP AAWPRIKPIF QTLAAKAGNN EPCCDWVGEQ 

       190        200        210        220        230        240 
GAGHYVKMVH NGIEYGDMQL ICETYDIMKR GLGMSCDEIA DVFEKWNTGK LDSFLIEITR 

       250        260        270        280        290        300 
DVLRYKADDG KPLVEKILDA AGQKGTGKWT AQNALEMGTP VSLITEAVFA RCLSSLKSER 

       310        320        330        340        350        360 
VRASKKLTGP NTKFTGDKKQ LIDDLEDALY ASKIISYAQG FMLMREAAKE YGWKLNNAGI 

       370        380        390        400        410        420 
ALMWRGGCII RSVFLKDITE AFREDPNLES ILFHPFFTNG VEKAQAGWRR VVAQAAMLGI 

       430        440        450        460        470        480 
PVPATSTGLS FYDGYRSAVL PANLLQAQRD YFGAHTFRVL PEAADKSLPA DKDIHINWTG 

       490 
HGGNISATTY DA 

P78812 in FASTA format

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