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UniProtKB/Swiss-Prot entry P71880

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAOX_MYCTU
Primary accession number P71880
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on August 29, 2001 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 59)
Name and origin of the protein
Protein name Putative malate oxidoreductase [NAD]
Synonyms EC 1.1.1.38
Malic enzyme
Gene name
Name: mez
OrderedLocusNames: Rv2332, MT2394
ORFNames: MTCY3G12.02c, MTCY98.01
From
Mycobacterium tuberculosis [TaxID: 1773] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1038/31159; PubMed=9634230 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 1551 / Oshkosh;
DOI=10.1128/JB.184.19.5479-5490.2002; PubMed=12218036 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX842579; CAB02059.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000516; AAK46686.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E70705; E70705.
RefSeq NP_216848.2; -.
NP_336872.1; -.
3D structure databases
HSSP P27443; 1LLQ. [HSSP ENTRY / PDB]
ModBase P71880.
Organism-specific databases
TubercuList Rv2332; -.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from EC).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS P71880.
ProtoNet P71880.
Genome annotation databases
GeneID 887962; -.
924018; -.
GenomeReviews AE000516_GR; MT2394.
AL123456_GR; Rv2332.
KEGG mtc:MT2394; -.
mtu:Rv2332; -.
TIGR MT2394; -.
Phylogenomic databases
HOGENOM P71880; -.
Other
LinkHub P71880; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   548  548     Putative malate oxidoreductase [NAD]. PRO_0000160248
ACT_SITE   96    96        Proton donor (By similarity). 
ACT_SITE   169   169        Proton acceptor (By similarity). 
METAL   240   240        Divalent metal cation (By similarity). 
METAL   241   241        Divalent metal cation (By similarity). 
METAL   264   264        Divalent metal cation (By similarity). 
BINDING   264   264        NAD (By similarity). 
BINDING   410   410        NAD (By similarity). 
SITE   264   264  1     Important for activity (By similarity). 
Sequence information
Length: 548 AA [This is the length of the unprocessed precursor] Molecular weight: 59423 Da [This is the MW of the unprocessed precursor] CRC64: 407248FE6BDFC875 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSDARVPRIP AALSAPSLNR GVGFTHAQRR RLGLTGRLPS AVLTLDQQAE RVWHQLQSLA 

        70         80         90        100        110        120 
TELGRNLLLE QLHYRHEVLY FKVLADHLPE LMPVVYTPTV GEAIQRFSDE YRGQRGLFLS 

       130        140        150        160        170        180 
IDEPDEIEEA FNTLGLGPED VDLIVCTDAE AILGIGDWGV GGIQIAVGKL ALYTAGGGVD 

       190        200        210        220        230        240 
PRRCLAVSLD VGTDNEQLLA DPFYLGNRHA RRRGREYDEF VSRYIETAQR LFPRAILHFE 

       250        260        270        280        290        300 
DFGPANARKI LDTYGTDYCV FNDDMQGTGA VVLAAVYSGL KVTGIPLRDQ TIVVFGAGTA 

       310        320        330        340        350        360 
GMGIADQIRD AMVADGATLE QAVSQIWPID RPGLLFDDMD DLRDFQVPYA KNRHQLGVAV 

       370        380        390        400        410        420 
GDRVGLSDAI KIASPTILLG CSTVYGAFTK EVVEAMTASC KHPMIFPLSN PTSRMEAIPA 

       430        440        450        460        470        480 
DVLAWSNGRA LLATGSPVAP VEFDETTYVI GQANNVLAFP GIGLGVIVAG ARLITRRMLH 

       490        500        510        520        530        540 
AAAKAIAHQA NPTNPGDSLL PDVQNLRAIS TTVAEAVYRA AVQDGVASRT HDDVRQAIVD 


TMWLPAYD
P71880 in FASTA format

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