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UniProtKB/Swiss-Prot entry P70385

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHB3_MOUSE
Primary accession number P70385
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on February 1, 1997 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 56)
Name and origin of the protein
Protein name Testosterone 17-beta-dehydrogenase 3
Synonyms EC 1.1.1.64
Testicular 17-beta-hydroxysteroid dehydrogenase
17-beta-HSD 3
Gene name
Name: Hsd17b3
Synonyms: Edh17b3
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
DOI=10.1016/S0960-0760(96)00165-3; PubMed=9182854 [NCBI, ExPASy, EBI, Israel, Japan]
Sha J.A., Dudley K., Rajapaksha W.R.A.K.J.S., O'Shaughnessy P.J.;
"Sequence of mouse 17beta-hydroxysteroid dehydrogenase type 3 cDNA and tissue distribution of the type 1 and type 3 isoform mRNAs.";
J. Steroid Biochem. Mol. Biol. 60:19-24(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U66827; AAB06793.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_032317.2; -.
UniGene Mm.5109
3D structure databases
ModBase P70385.
Organism-specific databases
MGI MGI:107177; Hsd17b3.
Gene expression databases
ArrayExpress P70385; -.
CleanEx MM_HSD17B3; -.
GermOnline ENSMUSG00000033122; Mus musculus.
Ontologies
GO
GO:0047045; Molecular function: testosterone 17-beta-dehydrogenase (NADP+) activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006694; Biological process: steroid biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR00081; GDHRDH.
PR00080; SDRFAMILY.
PROSITE PS00061; ADH_SHORT; 1.
BLOCKS P70385.
ProtoNet P70385.
Genome annotation databases
Ensembl ENSMUSG00000033122; Mus musculus. [Contig view]
GeneID 15487; -.
KEGG mmu:15487; -.
Phylogenomic databases
HOGENOM P70385; -.
HOVERGEN P70385; -.
Other
NextBio 288354; -.
SOURCE Hsd17b3; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Lipid synthesis; NADP; Oxidoreductase; Steroid biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   305  305     Testosterone 17-beta-dehydrogenase 3. PRO_0000054574
NP_BIND   44    73  30     NADP (By similarity). 
ACT_SITE   194   194        Proton acceptor (By similarity). 
BINDING   181   181        Substrate (By similarity). 
Sequence information
Length: 305 AA [This is the length of the unprocessed precursor] Molecular weight: 34271 Da [This is the MW of the unprocessed precursor] CRC64: 183860C85213EB61 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEKLFIAAGL FVGLVCLVKC MRFSQHLFLR FCKALPSSFL RSMGQWAVIT GAGDGIGKAY 

        70         80         90        100        110        120 
SFELARHGLN VVLISRTLEK LQTIAEEIER TTGSGVKIVQ ADFTREDIYD HIKEHLEGLE 

       130        140        150        160        170        180 
NGILVNNVGM LPSFFPSHFL SSSGESQNLI HCNITSVVKM TQLVLKHMES RRKGLILNIS 

       190        200        210        220        230        240 
SGAALRPWPL YSLYSASKAF VYTFSKALSV EYRDKGIIIQ VLTPYSISTP MTKYLNNKMT 

       250        260        270        280        290        300 
KTADEFVKES LKYVTIGAES CGCLAHEIIA IILNRIPSRI FYSSTAQRFL LTRYSDYLKR 


NISNR
P70385 in FASTA format

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