NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1016/S0140-6736(02)08713-5; PubMed=12044378 [NCBI, ExPASy, EBI, Israel, Japan]
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
"Genome and virulence determinants of high virulence community-acquired MRSA.";
Lancet 359:1819-1827(2002).

Comments

FUNCTION: Catalyzes the reversible reduction of acetoin to 2,3-butanediol in the presence of NADH (By similarity).
CATALYTIC ACTIVITY: Acetoin + NAD⁺ = diacetyl + NADH.
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000033; BAB93965.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_644915.1; -.

3D structure databases

HSSP

Q48436; 1GEG. [HSSP ENTRY / PDB]

ModBase

P66776.

Enzyme and pathway databases

BioCyc

SAUR196620:MW0100-MON; -.

Ontologies

GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR014007; 23BDH.
IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

TIGRFAMs

TIGR02415; 23BDH; 1.

PROSITE

PS00061; ADH_SHORT; 1.

Genome annotation databases

GeneID

1004853; -.

GenomeReviews

BA000033_GR; MW0100.

KEGG

sam:MW0100; -.

Phylogenomic databases

HOGENOM

P66776; -.

Genome annotation databases

CMR

P66776; MW0100.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 258`	`258`	`Acetoin(diacetyl) reductase.`	`PRO_0000054544`
`NP_BIND`	`8 32`	`25`	`NAD (By similarity).`
`ACT_SITE`	`154 154`		`Proton acceptor (By similarity).`
`ACT_SITE`	`158 158`		`By similarity.`
`BINDING`	`141 141`		`Substrate (By similarity).`

Sequence information

Length: 258 AA [This is the length of the unprocessed precursor]

Molecular weight: 27216 Da [This is the MW of the unprocessed precursor]

CRC64: 114AFD0DC5D780CF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTNNKVALVT GGAQGIGFKI AERLVEDGFK VAVVDFNEEG AKAAALKLSS DGTKAIAIKA 

        70         80         90        100        110        120 
DVSNRDDVFN AVRQTAAQFG DFHVMVNNAG LGPTTPIDTI TEEQFKTVYG VNVAGVLWGI 

       130        140        150        160        170        180 
QAAHEQFKKF NHGGKIINAT SQAGVEGNPG LSLYCSTKFA VRGLTQVAAQ DLASEGITVN 

       190        200        210        220        230        240 
AFAPGIVQTP MMESIAVATA EEAGKPEAWG WEQFTSQIAL GRVSQPEDVS NVVSFLAGKD 

       250 
SDYITGQTII VDGGMRFR

P66776 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools