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UniProtKB/Swiss-Prot entry P62052

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH1_LACJO
Primary accession number P62052
Secondary accession numbers None
Integrated into Swiss-Prot on June 21, 2004
Sequence was last modified on June 21, 2004 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 38)
Name and origin of the protein
Protein name L-lactate dehydrogenase 1
Synonyms L-LDH 1
EC 1.1.1.27
Gene name
Name: ldh1
OrderedLocusNames: LJ_0274
From
Lactobacillus johnsonii [TaxID: 33959] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCC 533;
DOI=10.1073/pnas.0307327101; PubMed=14983040 [NCBI, ExPASy, EBI, Israel, Japan]
Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C., Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R., Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
"The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533.";
Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017198; AAS08257.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_964291.1; -.
3D structure databases
ModBase P62052.
Enzyme and pathway databases
BioCyc LJOH257314:LJ_0274-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS P62052.
ProtoNet P62052.
Genome annotation databases
GeneID 2742935; -.
GenomeReviews AE017198_GR; LJ_0274.
KEGG ljo:LJ0274; -.
NMPDR fig|257314.1.peg.277; -.
Phylogenomic databases
HOGENOM P62052; -.
Genome annotation databases
CMR P62052; LJ_0274.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   323  323     L-lactate dehydrogenase 1. PRO_0000168349
NP_BIND   15    43  29     NAD (By similarity). 
ACT_SITE   178   178        Proton acceptor (By similarity). 
BINDING   91    91        Substrate (By similarity). 
BINDING   123   123        NAD or substrate (By similarity). 
BINDING   154   154        Substrate (By similarity). 
BINDING   232   232        Substrate (By similarity). 
MOD_RES   223   223        Phosphotyrosine (By similarity). 
Sequence information
Length: 323 AA [This is the length of the unprocessed precursor] Molecular weight: 35079 Da [This is the MW of the unprocessed precursor] CRC64: B45657BECF852F85 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSEEKIHKII LVGDGAVGST YAFSLVQQGI AQELGIVDIV KERTQGDAID LADATPWIAP 

        70         80         90        100        110        120 
KTIYSAEYSD AKDADLVVIS AGAPQKPGET RLDLVNKNLK ILSSIVEPIV ESGFNGIFLV 

       130        140        150        160        170        180 
AANPVDILTH ATWRMSGFPK DRVIGSGTSL DTGRLQKVIG EMEHVDPRSV NAYMLGEHGD 

       190        200        210        220        230        240 
TEFPVWSYNN VGGVKVSDWV KAHPEVGENK LEAIHKEVAD MAYDIINKKG ATFYGIGTAL 

       250        260        270        280        290        300 
AFITKAILNN EHRVLPLSVP MDGEYGLHDI HIGTPAVVGR HGLEQVIEMP LNADEQAKME 

       310        320 
ASAKQLKEVM DKAFKETGVK VRQ
P62052 in FASTA format

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