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UniProtKB/Swiss-Prot entry P60858

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_CORDI
Primary accession number P60858
Secondary accession numbers None
Integrated into Swiss-Prot on April 13, 2004
Sequence was last modified on April 13, 2004 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 36)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: DIP1566
From
Corynebacterium diphtheriae [TaxID: 1717] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Corynebacteriaceae; Corynebacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700971 / NCTC 13129 / Biotype gravis;
DOI=10.1093/nar/gkg874; PubMed=14602910 [NCBI, ExPASy, EBI, Israel, Japan]
Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G., Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S., Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., Parkhill J.;
"The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129.";
Nucleic Acids Res. 31:6516-6523(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX248358; CAE50091.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_939908.1; -.
3D structure databases
ModBase P60858.
Enzyme and pathway databases
BioCyc CDIP257309:DIP1566-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS P60858.
ProtoNet P60858.
Genome annotation databases
GeneID 2650755; -.
GenomeReviews BX248353_GR; DIP1566.
KEGG cdi:DIP1566; -.
NMPDR fig|257309.1.peg.1499; -.
Phylogenomic databases
HOGENOM P60858; -.
Genome annotation databases
CMR P60858; DIP1566.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   449  449     Histidinol dehydrogenase. PRO_0000135759
ACT_SITE   343   343        Proton acceptor (By similarity). 
ACT_SITE   344   344        Proton acceptor (By similarity). 
METAL   274   274        Zinc (By similarity). 
METAL   277   277        Zinc (By similarity). 
METAL   377   377        Zinc (By similarity). 
METAL   436   436        Zinc (By similarity). 
BINDING   135   135        NAD (By similarity). 
BINDING   199   199        NAD (By similarity). 
BINDING   229   229        NAD (By similarity). 
BINDING   252   252        Substrate (By similarity). 
BINDING   274   274        Substrate (By similarity). 
BINDING   277   277        Substrate (By similarity). 
BINDING   344   344        Substrate (By similarity). 
BINDING   377   377        Substrate (By similarity). 
BINDING   431   431        Substrate (By similarity). 
BINDING   436   436        Substrate (By similarity). 
Sequence information
Length: 449 AA [This is the length of the unprocessed precursor] Molecular weight: 47762 Da [This is the MW of the unprocessed precursor] CRC64: 002BB36B98F433FB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRKRKIMLNV IDLRGHVPTT SELRRTLPRG GTDINSVLPI VEPVVTDVKN RGAAAALDYG 

        70         80         90        100        110        120 
EKFDHVRPTS IRVPQDVIDQ ALDSLDPNVI EALKESIARV RAVHSEQLPA QHTTSFGEGA 

       130        140        150        160        170        180 
TITEKFIPVS RVGLYAPGGN AVYPSSVIMN VVPAQEAGVE SLVVASPPQK DHGGWPHPTI 

       190        200        210        220        230        240 
LAAAKLLGVT EVWAMGGAQA VALLAYGDDT QQNSAEVLEP VDMITGPGNI FVTAAKRLVR 

       250        260        270        280        290        300 
GVVGIDSEAG PTEIAIVADA QANPVWIAYD LISQAEHDVL AASVLITDSE ELAQRVNEEV 

       310        320        330        340        350        360 
AARYSVTRNA DRVSEALKGQ QSGIVLVDDL PTAVIVADAY AAEHLEIHTA ESHKVAEQIR 

       370        380        390        400        410        420 
NAGAIFVGGY SPVPLGDYSA GSNHVLPTSG SARYSSGLST HTFLKPVNVI YYDEVALKEI 

       430        440 
SDTVITLADA EDLPAHGEAI RTRFENLGN
P60858 in FASTA format

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