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UniProtKB/Swiss-Prot entry P59050

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH1_BIFLO
Primary accession number P59050
Secondary accession numbers None
Integrated into Swiss-Prot on October 19, 2002
Sequence was last modified on October 19, 2002 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 46)
Name and origin of the protein
Protein name L-lactate dehydrogenase 1
Synonyms L-LDH 1
EC 1.1.1.27
Gene name
Name: ldh1
OrderedLocusNames: BL0710
From
Bifidobacterium longum [TaxID: 216816] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Bifidobacteriales; Bifidobacteriaceae; Bifidobacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCC 2705;
DOI=10.1073/pnas.212527599; PubMed=12381787 [NCBI, ExPASy, EBI, Israel, Japan]
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract.";
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE014295; AAN24529.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_695893.1; -.
3D structure databases
HSSP P00344; 2LDB. [HSSP ENTRY / PDB]
ModBase P59050.
Enzyme and pathway databases
BioCyc BLON206672:BL0710-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS P59050.
ProtoNet P59050.
Genome annotation databases
GeneID 1023257; -.
GenomeReviews AE014295_GR; BL0710.
KEGG blo:BL0710; -.
NMPDR fig|206672.1.peg.660; -.
Phylogenomic databases
HOGENOM P59050; -.
Genome annotation databases
CMR P59050; BL0710.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   316  316     L-lactate dehydrogenase 1. PRO_0000168330
NP_BIND   15    43  29     NAD (By similarity). 
ACT_SITE   179   179        Proton acceptor (By similarity). 
BINDING   92    92        Substrate (By similarity). 
BINDING   124   124        NAD or substrate (By similarity). 
BINDING   155   155        Substrate (By similarity). 
BINDING   234   234        Substrate (By similarity). 
Sequence information
Length: 316 AA [This is the length of the unprocessed precursor] Molecular weight: 33871 Da [This is the MW of the unprocessed precursor] CRC64: E7A68E9A00992108 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MVTMNRNKVV IVGTGQVGAT AAFGIVTHGL CNELVLIDCS AAKALGEARD LDDGSEFQDR 

        70         80         90        100        110        120 
HVKVRAGDYA DCKDADIVVI TVGRKPPANS NRMAELGFTV GLVGEVVDNV MASGFDGVIV 

       130        140        150        160        170        180 
MVSNPVDVMA WYAWKRSGLP RTQVLGTGTA LDTSRLKTII GEETGLDPRN VGGFVMGEHG 

       190        200        210        220        230        240 
DSQFTAWSTV SLGGKPFARF LADNQDRFAS VSTTEIEEKT RTRGNEIVAA KGGTNFGIAS 

       250        260        270        280        290        300 
TVAGIVQTIL WDERRIVPVS TLLDGEYGEH DVFLGVPTEL RANGANEIVE LDLSEDERAK 

       310 
LHHSAELVRE HCEGLL
P59050 in FASTA format

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