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UniProtKB/Swiss-Prot entry P57201

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_BUCAI
Primary accession number P57201
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on December 1, 2000 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 49)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: BU100
From
Buchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) [TaxID: 118099] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tokyo 1998;
DOI=10.1038/35024074; PubMed=10993077 [NCBI, ExPASy, EBI, Israel, Japan]
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS.";
Nature 407:81-86(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000003; BAB12819.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_239933.1; -.
3D structure databases
HSSP P06988; 1KAE. [HSSP ENTRY / PDB]
ModBase P57201.
Enzyme and pathway databases
BioCyc BSP107806:BU100-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS P57201.
ProtoNet P57201.
Genome annotation databases
GeneID 1109503; -.
GenomeReviews BA000003_GR; BU100.
KEGG buc:BU100; -.
Phylogenomic databases
HOGENOM P57201; -.
Genome annotation databases
CMR P57201; BU100.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   435  435     Histidinol dehydrogenase. PRO_0000135742
ACT_SITE   327   327        Proton acceptor (By similarity). 
ACT_SITE   328   328        Proton acceptor (By similarity). 
METAL   260   260        Zinc (By similarity). 
METAL   263   263        Zinc (By similarity). 
METAL   361   361        Zinc (By similarity). 
METAL   420   420        Zinc (By similarity). 
BINDING   131   131        NAD (By similarity). 
BINDING   189   189        NAD (By similarity). 
BINDING   212   212        NAD (By similarity). 
BINDING   238   238        Substrate (By similarity). 
BINDING   260   260        Substrate (By similarity). 
BINDING   263   263        Substrate (By similarity). 
BINDING   328   328        Substrate (By similarity). 
BINDING   361   361        Substrate (By similarity). 
BINDING   415   415        Substrate (By similarity). 
BINDING   420   420        Substrate (By similarity). 
Sequence information
Length: 435 AA [This is the length of the unprocessed precursor] Molecular weight: 47844 Da [This is the MW of the unprocessed precursor] CRC64: 83DD3DDC4E43430E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKYFKNIIFW NKLHPDEQKK ILSRPILKEN NFIKKTVKEI IENVRLFGNS ALKKYTFLFD 

        70         80         90        100        110        120 
KQDINTFQVS KEKISSSSFY LSKVLKDSIS VAQKNITCFH KAQIPSKIDV ETEVGVRCEQ 

       130        140        150        160        170        180 
IYLPLNSIGI YIPGGTAPLF STVLMLAIPA KISGCKKIIL CSPPPISNEV LYAAHICGIH 

       190        200        210        220        230        240 
DIYQVGGAQA IAALALGTET VPKVDKIFGP GNAYVTEAKL QVSSIFNGTE IDMLAGPSEL 

       250        260        270        280        290        300 
LIIADNTANP DFIAADLLSQ AEHGVSSQVI LLTPCFELAE KVVLSINKQL NNLSRLSEIL 

       310        320        330        340        350        360 
KTLKNSSVII VKNLSECIEI SNMYAPEHLI IQTQSPREVL NYISNASSIF LGLWSPESAG 

       370        380        390        400        410        420 
DYASGTNHVL PTYGKSITNS SLGLCDFQKR VLVQELTAKG LMKLSNTIEI LSSAEKLQAH 

       430 
KNAVKIRVDF LKGKI
P57201 in FASTA format

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