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UniProtKB/Swiss-Prot entry P54996

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PD_FUGRU
Primary accession number P54996
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 52)
Name and origin of the protein
Protein name Glucose-6-phosphate 1-dehydrogenase
Synonyms G6PD
EC 1.1.1.49
Gene name
Name: g6pd
From
Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) [TaxID: 31033] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0888-7543(95)80179-P; PubMed=7607684 [NCBI, ExPASy, EBI, Israel, Japan]
Mason P.J., Stevens D.J., Luzzatto L., Brenner S., Aparicio S.;
"Genomic structure and sequence of the Fugu rubripes glucose-6-phosphate dehydrogenase gene (G6PD).";
Genomics 26:587-591(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X83611; CAA58590.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A56841; A56841.
3D structure databases
HSSP P11413; 1QKI. [HSSP ENTRY / PDB]
SMR P54996; 43-530.
ModBase P54996.
Ontologies
GO
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000110; G6PD; 1.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00871; zwf; 1.
PROSITE PS00069; G6P_DEHYDROGENASE; 1.
BLOCKS P54996.
ProtoNet P54996.
Genome annotation databases
Ensembl NEWSINFRUG00000135749; Fugu rubripes. [Contig view]
Phylogenomic databases
HOVERGEN P54996; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Glucose metabolism; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   530  530     Glucose-6-phosphate 1-dehydrogenase. PRO_0000068088
ACT_SITE   278   278        Proton acceptor (By similarity). 
BINDING   55    55        NADP (By similarity). 
BINDING   87    87        NADP (By similarity). 
BINDING   216   216        Substrate (By similarity). 
BINDING   220   220        Substrate (By similarity). 
Sequence information
Length: 530 AA [This is the length of the unprocessed precursor] Molecular weight: 60469 Da [This is the MW of the unprocessed precursor] CRC64: FC73FB53D834EF29 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MMIILFNCFF CASFREDGQH PTVSLGGVWG AAKELHEDKE FHQSDVHVFI IMGASGDLAK 

        70         80         90        100        110        120 
KKIYPTLWWL FRDGLLPEQT YFVGFARSAL TVDAIRTSCM PYLKVTETES DRLSAFFSRN 

       130        140        150        160        170        180 
SYISGNYTAG GSFSELNAHI MSLPGASDAN RLFYLALPPT IYHSVTENIK HFCMSAKGWN 

       190        200        210        220        230        240 
RVIVEKPFGH DLQSSEELST HLSSLFTEDQ IYRIDHYLGK EMVQNLMVLR FGNRIFGPIW 

       250        260        270        280        290        300 
NRDNVACVVL TFKEPFGTQG RGGYFDDFGI IRDVMQNHML QMLCLVAMEK PASTNSDDVR 

       310        320        330        340        350        360 
DEKVKVLKCI VPASMSDVVL GQYVGDPEGE GDAKLGYLDD PTVPKGSTQA TFATVVLYVH 

       370        380        390        400        410        420 
NERWDGVPFI LRCGKALNER KAEVRLQFTD VPGDIFRNQC YRNELVVRVQ PNEAIYAKMM 

       430        440        450        460        470        480 
SKKPGVYFTP EETELDLTYK SRYKDVKLPD AYERLILDVF CGSQMHFVAS DELREAWRIF 

       490        500        510        520        530 
TPLLHQIEKE KPKPIPYKYG SRGPAEADEL EKRVGFRYEG TYKWVNPHRL
P54996 in FASTA format

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