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UniProtKB/Swiss-Prot entry P54960

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH_BLAGE
Primary accession number P54960
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 55)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Synonyms HMG-CoA reductase
EC 1.1.1.34
Gene name None
From
Blattella germanica (German cockroach) [TaxID: 6973] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Orthopteroidea; Dictyoptera; Blattaria; Blattellidae; Blattellinae; Blattella.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8477698 [NCBI, ExPASy, EBI, Israel, Japan]
Martinez-Gonzalez J., Buesa C., Piulachs M.D., Belles X., Hegardt F.G.;
"Molecular cloning, developmental pattern and tissue expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase of the cockroach Blattella germanica.";
Eur. J. Biochem. 213:233-241(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X70034; CAA49628.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S30338; S30338.
3D structure databases
HSSP P04035; 1DQA. [HSSP ENTRY / PDB]
ModBase P54960.
Ontologies
GO
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
IPR004816; HMG_CoA_Rdtase_I_metazoan.
IPR000731; SSD_5TM.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00920; 2A060605; 1.
TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PS50156; SSD; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P54960.
ProtoNet P54960.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Glycoprotein; Isoprene biosynthesis; Membrane; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   856  856     3-hydroxy-3-methylglutaryl-coenzyme A reductase. PRO_0000114430
TRANSMEM   12    32  21     Potential. 
TRANSMEM   89   109  21     Potential. 
TRANSMEM   123   143  21     Potential. 
TRANSMEM   190   210  21     Potential. 
TRANSMEM   344   364  21     Potential. 
REGION   365   443  79     Linker. 
REGION   443   771  329     Catalytic. 
ACT_SITE   528   528        Charge relay system (By similarity). 
ACT_SITE   659   659        Charge relay system (By similarity). 
ACT_SITE   735   735        Charge relay system (By similarity). 
ACT_SITE   834   834        Proton donor (By similarity). 
CARBOHYD   326   326        N-linked (GlcNAc...) (Potential). 
CARBOHYD   412   412        N-linked (GlcNAc...) (Potential). 
CARBOHYD   700   700        N-linked (GlcNAc...) (Potential). 
CARBOHYD   838   838        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 856 AA [This is the length of the unprocessed precursor] Molecular weight: 93157 Da [This is the MW of the unprocessed precursor] CRC64: 833273836FC55AAA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MVGRLFRAHG QFCASHPWEV IVATLTLTVC MLTVDQRPLG LPPGWGHNCI TLEEYNAADM 

        70         80         90        100        110        120 
IVMTLIRCVA VLYSYYQFCH LQKLGSKYIL GIAGLFTVFS SFVFSSSVIN FLGSDVSDLK 

       130        140        150        160        170        180 
DALFFFLLLI DLSKATVLAQ FALSSRSQDE VKHNIARGIA MLGPTITLDT VVETLVIGVG 

       190        200        210        220        230        240 
MLSGVRRLEV LCCFACMSVI VNYVVFMTFY PACLSLILEL SRSGESGRPA WHDKSLIIKA 

       250        260        270        280        290        300 
LHEEDQKPNP VVQRVKVIMS AGLMLVHAHR WVRCLSIALW PDLTSLRYFC THCDTGVSYS 

       310        320        330        340        350        360 
RWSFASEGEE LPTVKLVTGD SVVNSNSTDD AQLHYYIMRW LTVSADHIVI LILLLALAVK 

       370        380        390        400        410        420 
FVFFETRDEL TTTRGMDGWV EVSSPVEHKY VQTEQPSCSA PEQPLEEPPA SNRSIDECLS 

       430        440        450        460        470        480 
VCKSDVGAQA LSDCEVMALV TSGHIAGYQL EKVVRNPERG VGIRRQILTK TADLKDALDN 

       490        500        510        520        530        540 
LPYKNYDYLK VMGACCENVI GYMPVPVGVA GPLNLDGRLV HVPLATTEGC LVASTNRGMR 

       550        560        570        580        590        600 
ALMRCGVTSR IVADGMTRGP VVRFPNIDRA SEAMLWMQVP YNFEQIKKNF DSTSRFARLS 

       610        620        630        640        650        660 
KIHIRVAGRH LFIRFIATTG DAMGMNMLSK GTEVALAYVQ QVYPDMEILS LSGNFCTDKK 

       670        680        690        700        710        720 
PAAVNWIEGR GKSVVCEAIV PADIIKSVLK TSVQALMDVN ITKNLIGSAV AGSIGGFNAH 

       730        740        750        760        770        780 
AANIVTAIFI ATGQDPAQNV GSSNCMTLME PWGEDGKDLY VSCTMPSIEI GTIGGGTVLP 

       790        800        810        820        830        840 
PQAACLDMLG VRGANEMCPG ENANTLARIV CGTVLAGELS LMSALAAGHL VKSHMRHNRS 

       850 
SVSTSGSEPS TPACKS
P54960 in FASTA format

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