ID   DHOM_SYNY3              Reviewed;         433 AA.
AC   P52986;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   04-NOV-2008, entry version 51.
DE   RecName: Full=Homoserine dehydrogenase;
DE            Short=HDH;
DE            EC=1.1.1.3;
GN   Name=hom; OrderedLocusNames=sll0455;
OS   Synechocystis sp. (strain PCC 6803).
OC   Bacteria; Cyanobacteria; Chroococcales; Synechocystis.
OX   NCBI_TaxID=1148;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=96127529; PubMed=8590279; DOI=10.1093/dnares/2.4.153;
RA   Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N.,
RA   Sugiura M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb
RT   region from map positions 64% to 92% of the genome.";
RL   DNA Res. 2:153-166(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=97061201; PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T.,
RA   Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S.,
RA   Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M.,
RA   Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the
RT   entire genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- CATALYTIC ACTIVITY: L-homoserine + NAD(P)(+) = L-aspartate 4-
CC       semialdehyde + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC   -!- SIMILARITY: Contains 1 ACT domain.
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DR   EMBL; BA000022; BAA10325.1; -; Genomic_DNA.
DR   PIR; S74407; S74407.
DR   RefSeq; NP_442255.1; -.
DR   IntAct; P52986; -.
DR   GeneID; 952451; -.
DR   GenomeReviews; BA000022_GR; sll0455.
DR   KEGG; syn:sll0455; -.
DR   NMPDR; fig|1148.1.peg.2356; -.
DR   HOGENOM; P52986; -.
DR   BioCyc; SSP1148:SLL0455-MON; -.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002912; ACT_bd.
DR   InterPro; IPR005106; Asp/hSer_DHase_NAD-bd.
DR   InterPro; IPR016204; hSer_DHase.
DR   InterPro; IPR001342; hSer_DHase_cat.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Complete proteome; Isoleucine biosynthesis; Methionine biosynthesis;
KW   NADP; Oxidoreductase; Threonine biosynthesis.
FT   CHAIN         1    433       Homoserine dehydrogenase.
FT                                /FTId=PRO_0000066704.
FT   DOMAIN      355    428       ACT.
FT   NP_BIND       8     15       NADP (By similarity).
FT   ACT_SITE    202    202       Proton donor (Potential).
FT   BINDING     102    102       NADP (By similarity).
FT   BINDING     187    187       Substrate (By similarity).
SQ   SEQUENCE   433 AA;  45486 MW;  4A7A034A7D2766B5 CRC64;
     MTVKIGLLGL GTVGSGTVEI LQDPQGRSPL LKAIEVKAVG VRSLDKPRQV NLPPEVLTTD
     LEAIVTDPDI AIVVELMGGL EPARSLILQA IAHKKHIVTA NKAVIARYGP EIYEAANQHG
     VYVLLEAAVG GGIPIIKPLK QSLGGNRIQS IVGILNGTTN YILSRMTSEG ADFDEVLTAA
     QQLGYAEADP SADVDGLDAA DKIAILASLG FGGRVKREDV ACEGIRSVSA VDIAYADRLG
     FVIKLLAIAD GNAGEDSEAL QLRVHPTLIA KDHPLASVNG VYNGVLVTGD PLGQVMFYGR
     GAGAGPTASA VVSDVINIVG IITSSDENPA LDPLLSCTHQ HYCQVSPIED LVTRFYCRFL
     CADVPGVIGH LGMGFGNHGV SLESLVQIGF TDGCAEIVVV THDVREGDYR AALEEISQLE
     AVKEIPSVIR VLS
//