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UniProtKB/Swiss-Prot entry P49383

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH2_KLULA
Primary accession number P49383
Secondary accession number Q6CJJ0
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on August 31, 2004 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 55)
Name and origin of the protein
Protein name Alcohol dehydrogenase 2
Synonyms EC 1.1.1.1
Alcohol dehydrogenase II
Gene name
Name: ADH2
OrderedLocusNames: KLLA0F18260g
From
Kluyveromyces lactis (Yeast) (Candida sphaerica) [TaxID: 28985] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37;
DOI=10.1007/BF00266253; PubMed=1588917 [NCBI, ExPASy, EBI, Israel, Japan]
Shain D.H., Salvadore C., Denis C.L.;
"Evolution of the alcohol dehydrogenase (ADH) genes in yeast: characterization of a fourth ADH in Kluyveromyces lactis.";
Mol. Gen. Genet. 232:479-488(1992).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37;
DOI=10.1038/nature02579; PubMed=15229592 [NCBI, ExPASy, EBI, Israel, Japan]
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X64397; CAA45739.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR382126; CAG98607.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S20911; S20911.
RefSeq XP_455899.1; -.
3D structure databases
HSSP P39462; 1JVB. [HSSP ENTRY / PDB]
SMR P49383; 2-348.
ModBase P49383.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
BLOCKS P49383.
ProtoNet P49383.
Genome annotation databases
GeneID 2894942; -.
KEGG kla:KLLA0F18260g; -.
Phylogenomic databases
HOGENOM P49383; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   348  348     Alcohol dehydrogenase 2. PRO_0000160723
METAL   44    44        Zinc 1; catalytic (By similarity). 
METAL   67    67        Zinc 1; catalytic (By similarity). 
METAL   98    98        Zinc 2 (By similarity). 
METAL   101   101        Zinc 2 (By similarity). 
METAL   104   104        Zinc 2 (By similarity). 
METAL   112   112        Zinc 2 (By similarity). 
METAL   154   154        Zinc 1; catalytic (By similarity). 
CONFLICT   84    84        N -> I (in Ref. 1; CAA45739). 
Sequence information
Length: 348 AA [This is the length of the unprocessed precursor] Molecular weight: 37098 Da [This is the MW of the unprocessed precursor] CRC64: F21D3DE1F6FB389C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSIPETQKGV IFYENGGELQ YKDIPVPKPK ANELLINVKY SGVCHTDLHA WKGDWPLPTK 

        70         80         90        100        110        120 
LPLVGGHEGA GVVVAMGENV KGWNIGDFAG IKWLNGSCMS CEYCELSNES NCPDADLSGY 

       130        140        150        160        170        180 
THDGSFQQYA TADAVQAARI PKGTDLAEVA PILCAGVTVY KALKSADLKA GDWVAISGAC 

       190        200        210        220        230        240 
GGLGSLAIQY AKAMGYRVLG IDTGAEKAKL FKELGGEYFV DYAVSKDLIK EIVDATNGGA 

       250        260        270        280        290        300 
HGVINVSVSE FAIEQSTNYV RSNGTVVLVG LPRDAKCKSD VFTQVVKSVS IVGSYVGNRA 

       310        320        330        340 
DTREALDFFA RGLVHAPIKI VGLSELADVY DKMVKGEIVG RYVVDTSK
P49383 in FASTA format

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