NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 21276;
PubMed=8117070 [NCBI, ExPASy, EBI, Israel, Japan]
Motoyama H., Maki K., Anazawa H., Ishino S., Teshiba S.;
"Cloning and nucleotide sequences of the homoserine dehydrogenase genes (hom) and the threonine synthase genes (thrC) of the Gram-negative obligate methylotroph Methylobacillus glycogenes.";
Appl. Environ. Microbiol. 60:111-119(1994).

Comments

CATALYTIC ACTIVITY: L-homoserine + NAD(P)⁺ = L-aspartate 4-semialdehyde + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3 .
PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5 .
SIMILARITY: Belongs to the homoserine dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D14070; BAA40414.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

P37143.

Family and domain databases

InterPro

IPR005106; Asp/hSer_DHase_NAD-bd.
IPR001342; hSer_DHase_cat.
Graphical view of domain structure.

Pfam

PF00742; Homoserine_dh; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.

PROSITE

PS01042; HOMOSER_DHGENASE; FALSE_NEG.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Isoleucine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Threonine biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 435`	`435`	`Homoserine dehydrogenase.`	`PRO_0000066698`
`NP_BIND`	`9 16`	`8`	`NADP (By similarity).`
`ACT_SITE`	`204 204`		`Proton donor (Potential).`
`BINDING`	`105 105`		`NADP (By similarity).`
`BINDING`	`190 190`		`Substrate (By similarity).`

Sequence information

Length: 435 AA [This is the length of the unprocessed precursor]

Molecular weight: 48227 Da [This is the MW of the unprocessed precursor]

CRC64: 58468B0E7A81ACAB [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKPINVGLLG IGTVGGGTYT VLTRNQEGNR APCRPPNCHH ARRDRNLELA RKVTGGQIDV 

        70         80         90        100        110        120 
TDDAFAVVVR PRHRHRGRID RRIHHRARTG YEGDRERQAR VAANKALMLA WQRDFRRVAQ 

       130        140        150        160        170        180 
QKGVIVAFEA AVAGGIPIIK AVAAGAGRQP SSRVLRAIIN GTTNFILSEM REKGLAFADV 

       190        200        210        220        230        240 
LKEAQPRLCE ATRPSTSRAW TAHKLMILAA IGFGIPMQFD KAYVEGISKL DALDIRYAEE 

       250        260        270        280        290        300 
LGYRQAAWHA PSAPARGVEL ARAPDPDPRE TPDRQCQRRH NAVLVSDACR SHLVYRPDAC 

       310        320        330        340        350        360 
RRHASAVVAD IVDGTRTAYH RRAPAVPHLL SSPTSSWTCR FAIGEVSSAY YLRLRAVDKP 

       370        380        390        400        410        420 
GRDGHVTRIL ATGSLHRCDD SEGNRRQAER RRSGRHHHPD HVTVEKNMDD AIVAIEALPA 

       430 
ISGSVTRLRM EELSR

P37143 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools