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UniProtKB/Swiss-Prot entry P34517

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GPDA_CAEEL
Primary accession number P34517
Secondary accession number Q8I4H2
Integrated into Swiss-Prot on February 1, 1994
Sequence was last modified on May 16, 2003 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 65)
Name and origin of the protein
Protein name Probable glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic
Synonym EC 1.1.1.8
Gene name
ORFNames: K11H3.1
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1038/368032a0; PubMed=7906398 [NCBI, ExPASy, EBI, Israel, Japan]
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P.;
"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.";
Nature 368:32-38(1994).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z22180; CAD54146.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S40754; S40754.
RefSeq NP_871632.1; -.
UniGene Cel.10288
3D structure databases
ModBase P34517.
Protein-protein interaction databases
IntAct P34517; -.
Organism-specific databases
WormBase WBGene00010778; K11H3.1.
WormPep K11H3.1b; CE31851. [WormPep / WorfDB]
Gene expression databases
ArrayExpress P34517; -.
Ontologies
GO
GO:0006973; Biological process: intracellular accumulation of glycerol (inferred from genetic interaction from WormBase).
QuickGo view.
Family and domain databases
InterPro IPR013328; DHase_multihelical.
IPR016040; NAD(P)-bd.
IPR017751; NAD-dep_Gly3P_DH_euk.
IPR006168; NAD-dep_Gly3P_DHase.
IPR011128; NAD-dep_Gly3P_DHase_N.
IPR006109; NAD_Gly3P_DHase_C.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
PANTHER PTHR11728; NAD_Gly3P_DH; 1.
Pfam PF07479; NAD_Gly3P_dh_C; 1.
PF01210; NAD_Gly3P_dh_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000114; Glycerol-3-P_dh; 1.
PRINTS PR00077; GPDHDRGNASE.
ProDom PD001278; NAD_Gly3P_C; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00957; NAD_G3PDH; 1.
BLOCKS P34517.
ProtoNet P34517.
Genome annotation databases
Ensembl K11H3.1; Caenorhabditis elegans. [Contig view]
GeneID 176399; -.
Other
NextBio 892406; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   392  392     Probable glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic. PRO_0000138070
NP_BIND   42    47  6     NAD (By similarity). 
REGION   312   313  2     Substrate binding (By similarity). 
ACT_SITE   248   248        Proton acceptor (By similarity). 
BINDING   130   130        NAD (By similarity). 
BINDING   153   153        NAD; via amide nitrogen (By similarity). 
BINDING   153   153        Substrate (By similarity). 
BINDING   196   196        NAD; via amide nitrogen (By similarity). 
BINDING   312   312        NAD (By similarity). 
BINDING   341   341        NAD (By similarity). 
Sequence information
Length: 392 AA [This is the length of the unprocessed precursor] Molecular weight: 42792 Da [This is the MW of the unprocessed precursor] CRC64: E42BCCBE280B04A5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSSSRIPQCE NSSRLSLSSI FRYFGTTSTI ATMSPKKVTI IGSGNWGSAI ARIVGSTTKS 

        70         80         90        100        110        120 
FPDEFDPTVR MWVFEEIVNG EKLSEVINNR HENIKYLPGK VLPNNVVAVT DLVESCEGSN 

       130        140        150        160        170        180 
VLVFVVPHQF VKGICEKLVG KIPADTQAIS LIKGISFDKT NQGVSTEKRG GLKLISEEIK 

       190        200        210        220        230        240 
EILKIEVSVL MGANLAPEVA NDNFCEATIG CKRKAEDGPL LKKLFHTDNF RINVVEDAHT 

       250        260        270        280        290        300 
VELCGALKNV VACAAGFTDG LGYGDNTKAA VIRLGLMETT KFVEHYYPGS NLQTFFESCG 

       310        320        330        340        350        360 
IADLITTCYG GRNRKVCEAF VKTGKSMAEV EKELLNGQSA QGPLTAEEVY LMMHKTGLDA 

       370        380        390 
KFPLFTAVHK ICAGEMKPAE LVDCLRNHPE HM
P34517 in FASTA format

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