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UniProtKB/Swiss-Prot entry O54939

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHB3_RAT
Primary accession number O54939
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on June 1, 1998 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 53)
Name and origin of the protein
Protein name Testosterone 17-beta-dehydrogenase 3
Synonyms EC 1.1.1.64
Testicular 17-beta-hydroxysteroid dehydrogenase
17-beta-HSD 3
Gene name
Name: Hsd17b3
Synonyms: Edh17b3
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Khanum A., Tsai-Morris C.-H., Dufau M.L.;
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF035156; AAB99739.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_446459.1; -.
UniGene Rn.10895
3D structure databases
ModBase O54939.
Organism-specific databases
RGD 621805; Hsd17b3.
Gene expression databases
ArrayExpress O54939; -.
GermOnline ENSRNOG00000019096; Rattus norvegicus.
Ontologies
GO
GO:0047045; Molecular function: testosterone 17-beta-dehydrogenase (NADP+) activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006694; Biological process: steroid biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR00081; GDHRDH.
PR00080; SDRFAMILY.
PROSITE PS00061; ADH_SHORT; FALSE_NEG.
BLOCKS O54939.
ProtoNet O54939.
Genome annotation databases
Ensembl ENSRNOG00000019096; Rattus norvegicus. [Contig view]
GeneID 117182; -.
KEGG rno:117182; -.
Phylogenomic databases
HOVERGEN O54939; -.
Other
NextBio 620038; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Lipid synthesis; NADP; Oxidoreductase; Steroid biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   306  306     Testosterone 17-beta-dehydrogenase 3. PRO_0000054575
NP_BIND   44    73  30     NADP (By similarity). 
ACT_SITE   194   194        Proton acceptor (By similarity). 
BINDING   181   181        Substrate (By similarity). 
Sequence information
Length: 306 AA [This is the length of the unprocessed precursor] Molecular weight: 34223 Da [This is the MW of the unprocessed precursor] CRC64: 8B88584047614B53 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEQFLLSVGL LVCLVCLVKC VRFSRYLFLS FCKALPGSFL RSMGQWAVIT GAGDGIGKAY 

        70         80         90        100        110        120 
SFELARHGLN VVLISRTLEK LQVISEEIER TTGSRVKVVQ ADFTREDIYD HIEEQLKGLE 

       130        140        150        160        170        180 
IGVLVNNVGM LPNLLPSHFL STSGESQSVI HCNITSVVKM TQLVLKHMES RRRGLILNIS 

       190        200        210        220        230        240 
SGVGVRPWPL YSLYSASKAF VCTFSKALNV EYRDKGIIIQ VLTPYSVSTP MTKYLNTSRV 

       250        260        270        280        290        300 
TKTADEFVKE SLKYVTIGAE TCGCLAHEIL AIILNLIPSR IFYSSTTQRF LLKQFSDYLK 


SNISNR
O54939 in FASTA format

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View entry in raw text format (no links)
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