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UniProtKB/Swiss-Prot entry O05973

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UDG_RICPR
Primary accession number O05973
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on July 1, 1997 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 53)
Name and origin of the protein
Protein name UDP-glucose 6-dehydrogenase
Synonyms UDP-Glc dehydrogenase
UDP-GlcDH
UDPGDH
EC 1.1.1.22
Gene name
Name: udg
OrderedLocusNames: RP779
From
Rickettsia prowazekii [TaxID: 782] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Madrid E;
PubMed=9274032 [NCBI, ExPASy, EBI, Israel, Japan]
Andersson J.O., Andersson S.G.E.;
"Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence.";
Microbiology 143:2783-2795(1997).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Madrid E;
DOI=10.1038/24094; PubMed=9823893 [NCBI, ExPASy, EBI, Israel, Japan]
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.;
"The genome sequence of Rickettsia prowazekii and the origin of mitochondria.";
Nature 396:133-140(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y11785; CAA72478.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ235273; CAA15205.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E71638; E71638.
RefSeq NP_221129.1; -.
3D structure databases
HSSP P11759; 1MFZ. [HSSP ENTRY / PDB]
ModBase O05973.
Enzyme and pathway databases
BioCyc RPRO272947:RP779-MON; -.
Ontologies
GO
GO:0003979; Molecular function: UDP-glucose 6-dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013328; DHase_multihelical.
IPR016040; NAD(P)-bd.
IPR017476; Nucleotide_sugar_DH.
IPR014027; UDP-Glc/GDP-Man_DHase_C.
IPR014026; UDP-Glc/GDP-Man_DHase_dimer.
IPR014028; UDP-Glc/GDP-Man_DHase_dimer-bd.
IPR001732; UDP-Glc/GDP-Man_DHase_N.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
PANTHER PTHR11374; UDPG_MGDP_DH_Creg; 1.
Pfam PF00984; UDPG_MGDP_dh; 1.
PF03720; UDPG_MGDP_dh_C; 1.
PF03721; UDPG_MGDP_dh_N; 1.
Pfam graphical view of domain structure.
BLOCKS O05973.
ProtoNet O05973.
Genome annotation databases
GeneID 883765; -.
GenomeReviews AJ235269_GR; RP779.
KEGG rpr:RP779; -.
Phylogenomic databases
HOGENOM O05973; -.
Genome annotation databases
CMR O05973; RP779.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   434  434     UDP-glucose 6-dehydrogenase. PRO_0000074052
NP_BIND   2    19  18     NAD (Potential). 
ACT_SITE   260   260        By similarity. 
Sequence information
Length: 434 AA [This is the length of the unprocessed precursor] Molecular weight: 48226 Da [This is the MW of the unprocessed precursor] CRC64: 15991BA7112D5036 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNITFIGSGY VGLVSGIIMG YLGHNVTCLD NDDVKISKLN KKILPIYEAK LDEYLKHALE 

        70         80         90        100        110        120 
SDRLKFTNIY SNEFRNFDAI FITVGTPSKE LGEADLKYVY DAVDKVSKHI NKDCLIVIKS 

       130        140        150        160        170        180 
TVPPGSCNNI IAYLKAKGFS FNVASNPEFL REGSAVEDFL YPDRIVVGVN NKESEALLRK 

       190        200        210        220        230        240 
IYAPLIEQGA KFLVTNLVTS ELIKYVSNSF LATKIAFINE MADLCEKIGA NIKDLSQGVG 

       250        260        270        280        290        300 
LDQRIGRNFL NAGPGFGGSC FPKDILALNN LVENHKIDCK ILKSVIKSNK LRPSNMVAKI 

       310        320        330        340        350        360 
ATLLDGDLKG RNIAILGLTY KAGTDDVRAS PAIEIITILL NKDVYVKAFD PIGLENAKKN 

       370        380        390        400        410        420 
LEHKNLLYFA SAVEACKSVD IIVIATEWSE FKELNWQEIY NLVKSPMIID LRNILDNEVM 

       430 
KKIGFRYYAV GSQI
O05973 in FASTA format

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