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UniProtKB/Swiss-Prot entry A0KG16

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH_AERHH
Primary accession number A0KG16
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on December 12, 2006 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 14)
Name and origin of the protein
Protein name Malate dehydrogenase
Synonym EC 1.1.1.37
Gene name
Name: mdh
OrderedLocusNames: AHA_0659
From
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [TaxID: 380703] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales; Aeromonadaceae; Aeromonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.00621-06; PubMed=16980456 [NCBI, ExPASy, EBI, Israel, Japan]
Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
J. Bacteriol. 188:8272-8282(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000462; ABK35951.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_855201.1; -.
3D structure databases
SMR A0KG16; 1-310.
ModBase A0KG16.
Ontologies
GO
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01516; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR010097; Malate_DHase_NAD-dep_euk_g_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11540:SF1; MDH_euk_g_bac; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
TIGRFAMs TIGR01772; MDH_euk_gproteo; 1.
PROSITE PS00068; MDH; 1.
BLOCKS A0KG16.
ProtoNet A0KG16.
Genome annotation databases
GeneID 4486843; -.
GenomeReviews CP000462_GR; AHA_0659.
KEGG aha:AHA_0659; -.
TIGR AHA_0659; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   311  311     Malate dehydrogenase. PRO_0000294292
NP_BIND   7    13  7     NAD (By similarity). 
NP_BIND   117   119  3     NAD (By similarity). 
ACT_SITE   177   177        Proton acceptor (By similarity). 
BINDING   34    34        NAD (By similarity). 
BINDING   81    81        Substrate (By similarity). 
BINDING   87    87        Substrate (By similarity). 
BINDING   94    94        NAD (By similarity). 
BINDING   119   119        Substrate (By similarity). 
BINDING   153   153        Substrate (By similarity). 
BINDING   227   227        NAD (By similarity). 
Sequence information
Length: 311 AA [This is the length of the unprocessed precursor] Molecular weight: 32113 Da [This is the MW of the unprocessed precursor] CRC64: B7976C035279DA6E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKVAVLGAAG GIGQALALLL KNRLPAGSEL SLYDIAPVTP GVAVDLSHIP TDVKVKGFCG 

        70         80         90        100        110        120 
EDPSPALVGA DVVLISAGVA RKPGMDRSDL FNINAGIVKN LVEKCAASCP KALIGIITNP 

       130        140        150        160        170        180 
VNTTVAIAAE VLKKAGVYDK RRLFGVTTLD VIRAETFVAE AKGLNVDKVR VNVIGGHSGV 

       190        200        210        220        230        240 
TILPLLSQIE GASFTADEVA AMTKRIQNAG TEVVEAKAGG GSATLSMGQA ACRFGLSLIK 

       250        260        270        280        290        300 
GLQGEANVIE CAYVEGDGKH ATFFAQPILL GKNGVETVLD YGKLSAFEQE AMDGMLATLK 

       310 
ADIQLGVEFV K
A0KG16 in FASTA format

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